@article{fdi:010072064,
  title = {{W}hole-genome sequencing of african dogs provides insights into adaptations against tropical parasites},
  author = {{L}iu, {Y}. {H}. and {W}ang, {L}. and {X}u, {T}. and {G}uo, {X}. {M}. and {L}i, {Y}. and {Y}in, {T}. {T}. and {Y}ang, {H}. {C}. and {H}u, {Y}. and {A}deola, {A}. {C}. and {S}anke, {O}. {J}. and {O}tecko, {N}. {O}. and {W}ang, {M}. and {M}a, {Y}. {P}. and {C}harles, {O}. {S}. and {S}inding, {M}. {H}. {S}. and {G}opalakrishnan, {S}. and {S}amaniego, {J}. {A}. and {H}ansen, {A}. {J}. and {F}ernandes, {C}. and {G}aubert, {P}hilippe and {B}udd, {J}. and {D}awuda, {P}. {M}. and {R}ueness, {E}. {K}. and {J}iang, {L}. {B}. and {Z}hai, {W}. {W}. and {G}ilbert, {M}. {T}. {P}. and {P}eng, {M}. {S}. and {Q}i, {X}. {P}. and {W}ang, {G}. {D}. and {Z}hang, {Y}. {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{N}atural selection in domestic dogs is of great interest in evolutionary biology since dogs havemigrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. {H}ere, we explored their demographic history and genetic basis of adaptation to the tropical {A}frican environment using whole genome analyses of 19 {A}frican indigenous dogs from {N}igeria. {D}emographic analysis suggests that the ancestors of these dogs migrated into {A}frica from {E}urasia 14,000 years ago and underwent a severe founder effect before population expansion. {A}dmixture analysis further reveals that {A}frican dog genomes contain about 1.88-3.50% introgression from {A}frican golden wolves ({C}anis anthus). {P}opulation genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. {O}ne of the positively selected genes, adhesion {G} protein-coupled receptor {E}1 ({ADGRE}1), has also been found to be association with severe malaria resistance in {A}frican human populations. {F}unctional assessments showed that {ADGRE}1 provides protective host defense against {P}lasmodium infections. {T}his result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.},
  keywords = {{A}frican dogs ; adaptive evolution ; antiparasite ; demographic history ; {AFRIQUE} ; {ASIE} ; {MOYEN} {ORIENT} ; {EUROPE} ; {CHINE} ; {NIGERIA} ; {SENEGAL} ; {ALGERIE} ; {EGYPTE} ; {MAROC}},
  booktitle = {},
  journal = {{M}olecular {B}iology and {E}volution},
  volume = {35},
  numero = {2},
  pages = {287--298},
  ISSN = {0737-4038},
  year = {2018},
  DOI = {10.1093/molbev/msx258},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072064},
}