%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Zeng, L.
%A Ming, C.
%A Li, Y.
%A Su, L. Y.
%A Su, Y. H.
%A Otecko, N. O.
%A Dalecky, Ambroise
%A Donnellan, S.
%A Aplin, K.
%A Liu, X. H.
%A Song, Y.
%A Zhang, Z. B.
%A Esmailizadeh, A.
%A Sohrabi, S. S.
%A Nanaei, H. A.
%A Liu, H. Q.
%A Wang, M. S.
%A Atteynine, S. A.
%A Rocamora, G.
%A Brescia, F.
%A Morand, S.
%A Irwin, D. M.
%A Peng, M. S.
%A Yao, Y. G.
%A Li, H. P.
%A Wu, D. D.
%A Zhang, Y. P.
%T Out of Southern East Asia of the brown rat revealed by large-scale genome sequencing
%D 2018
%L fdi:010071984
%G ENG
%J Molecular Biology and Evolution
%@ 0737-4038
%K Rattus norvegicus ; origin ; demographic history ; natural selection
%K ASIE SUD EST ; ASIE NORD EST ; MOYEN ORIENT ; AFRIQUE ; EUROPE
%M ISI:000419548800013
%N 1
%P 149-158
%R 10.1093/molbev/msx276
%U https://www.documentation.ird.fr/hor/fdi:010071984
%> https://www.documentation.ird.fr/intranet/publi/2018/01/010071984.pdf
%V 35
%W Horizon (IRD)
%X The geographic origin and migration of the brown rat (Rattus norvegicus) remain subjects of considerable debate. In this study, we sequenced whole genomes of 110 wild brown rats with a diverse world-wide representation. We reveal that brown rats migrated out of southern East Asia, rather than northern Asia as formerly suggested, into the Middle East and then to Europe and Africa, thousands of years ago. Comparison of genomes from different geographical populations reveals that many genes involved in the immune system experienced positive selection in the wild brown rat.
%$ 080