@article{fdi:010071984, title = {{O}ut of {S}outhern {E}ast {A}sia of the brown rat revealed by large-scale genome sequencing}, author = {{Z}eng, {L}. and {M}ing, {C}. and {L}i, {Y}. and {S}u, {L}. {Y}. and {S}u, {Y}. {H}. and {O}tecko, {N}. {O}. and {D}alecky, {A}mbroise and {D}onnellan, {S}. and {A}plin, {K}. and {L}iu, {X}. {H}. and {S}ong, {Y}. and {Z}hang, {Z}. {B}. and {E}smailizadeh, {A}. and {S}ohrabi, {S}. {S}. and {N}anaei, {H}. {A}. and {L}iu, {H}. {Q}. and {W}ang, {M}. {S}. and {A}tteynine, {S}. {A}. and {R}ocamora, {G}. and {B}rescia, {F}. and {M}orand, {S}. and {I}rwin, {D}. {M}. and {P}eng, {M}. {S}. and {Y}ao, {Y}. {G}. and {L}i, {H}. {P}. and {W}u, {D}. {D}. and {Z}hang, {Y}. {P}.}, editor = {}, language = {{ENG}}, abstract = {{T}he geographic origin and migration of the brown rat ({R}attus norvegicus) remain subjects of considerable debate. {I}n this study, we sequenced whole genomes of 110 wild brown rats with a diverse world-wide representation. {W}e reveal that brown rats migrated out of southern {E}ast {A}sia, rather than northern {A}sia as formerly suggested, into the {M}iddle {E}ast and then to {E}urope and {A}frica, thousands of years ago. {C}omparison of genomes from different geographical populations reveals that many genes involved in the immune system experienced positive selection in the wild brown rat.}, keywords = {{R}attus norvegicus ; origin ; demographic history ; natural selection ; {ASIE} {SUD} {EST} ; {ASIE} {NORD} {EST} ; {MOYEN} {ORIENT} ; {AFRIQUE} ; {EUROPE}}, booktitle = {}, journal = {{M}olecular {B}iology and {E}volution}, volume = {35}, numero = {1}, pages = {149--158}, ISSN = {0737-4038}, year = {2018}, DOI = {10.1093/molbev/msx276}, URL = {https://www.documentation.ird.fr/hor/fdi:010071984}, }