@article{fdi:010071963,
  title = {{V}irologic response to early antiretroviral therapy in {HIV}-infected infants : evaluation after 2 years of treatment in the pediacam study, {C}ameroon},
  author = {{N}dongo, {F}. {A}. and {T}exier, {G}. and {P}enda, {C}. {I}. and {T}ejiokem, {M}. {C}. and {N}diang, {S}. {T}. and {N}dongo, {J}. {A}. and {G}uemkam, {G}. and {S}ofeu, {C}. {L}. and {K}futwah, {A}. and {F}aye, {A}. and {M}sellati, {P}hilippe and {W}arszawski, {J}. and {ANRS}-{P}ediacam {S}tudy {G}roup},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction: {L}ittle is known about virologic responses to early antiretroviral therapy ({ART}) in {HIV}-infected infants in resource-limited settings. {W}e estimated the probability of achieving viral suppression within 2 years of {ART} initiation and investigated the factors associated with success. {M}ethods: {W}e analyzed all 190 infants from the {C}ameroon {P}ediacam who initiated {ART} by 12 months of age. {T}he main outcome measure was viral suppression (<1000 copies/m{L}) on at least 1 occasion; the other outcome measures considered were viral suppression (<400 copies/m{L}) on at least 1 occasion and confirmed viral suppression (both thresholds) on 2 consecutive occasions. {W}e used competing-risks regression for a time-to-event analysis to estimate the cumulative incidence of outcomes and univariate and multivariate models to identify risk factors. {R}esults: {D}uring the first 24 months of {ART}, 20.0% (38) of the infants died, giving a mortality rate of 11.9 deaths per 100 infant-years (95% confidence interval: 8.1-15.7). {T}he probability of achieving a viral load below 1000 or 400 copies/m{L} was 80.0% (69.0-81.0) and 78.0% (66.0-79.0), respectively. {T}he probability of virologic suppression (with these 2 thresholds) on 2 consecutive occasions was 67.0% (56.0-70.0) and 60.0% (49.0-64.0), respectively. {V}irologic success was associated with not having missed any doses of treatment before the visit, but not with socioeconomic and living conditions. {C}onclusion: {M}any early treated children failed to achieve virologic suppression, likely due to a combination of adherence difficulties, drug dosing and viral resistance, which highlights the need for routine viral load monitoring. {T}he high infant mortality despite early {ART} initiation needs to be addressed in sub-{S}aharan countries.},
  keywords = {{HIV}-infected infants ; antiretroviral treatment ; virologic success ; {CAMEROUN}},
  booktitle = {},
  journal = {{P}ediatric {I}nfectious {D}isease {J}ournal},
  volume = {37},
  numero = {1},
  pages = {78--84},
  ISSN = {0891-3668},
  year = {2018},
  DOI = {10.1097/inf.0000000000001745},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071963},
}