@article{fdi:010071956,
  title = {{G}enetic diversity of the {A}frican malaria vector {A}nopheles gambiae},
  author = {{T}he {A}nopheles gambiae 1000 {G}enomes {C}onsortium and {A}yala, {D}iego and {C}ostantini, {C}arlo},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he sustainability of malaria control in {A}frica is threatened by the rise of insecticide resistance in {A}nopheles mosquitoes, which transmit the disease(1). {T}o gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of {A}nopheles gambiae and {A}nopheles coluzzii sampled from 15 locations across {A}frica, and identified over 50 million single nucleotide polymorphisms within the accessible genome. {T}hese data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. {S}trong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. {T}he design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.},
  keywords = {{AFRIQUE}},
  booktitle = {},
  journal = {{N}ature},
  volume = {552},
  numero = {7683},
  pages = {96--100 + 14 p.},
  ISSN = {0028-0836},
  year = {2017},
  DOI = {10.1038/nature24995},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071956},
}