Makinson A., Hayot M., Eymard-Duvernay Sabrina, Ribet C., Raffi F., Pialoux G., Zucman D., Poizot-Martin I., Bonnet F., Abgrall S., Tattevin P., Cheret A., Ferry T., Mauboussin J. M., Marchand L., Rouzaud C., Reynes J., Zins M., Le Moing V., ANRS EP48 HIV CHEST study Team. (2018). HIV is associated with airway obstruction : a matched controlled study. Aids, 32 (2), p. 227-232. ISSN 0269-9370.
Titre du document
HIV is associated with airway obstruction : a matched controlled study
Année de publication
2018
Auteurs
Makinson A., Hayot M., Eymard-Duvernay Sabrina, Ribet C., Raffi F., Pialoux G., Zucman D., Poizot-Martin I., Bonnet F., Abgrall S., Tattevin P., Cheret A., Ferry T., Mauboussin J. M., Marchand L., Rouzaud C., Reynes J., Zins M., Le Moing V., ANRS EP48 HIV CHEST study Team
Source
Aids, 2018,
32 (2), p. 227-232 ISSN 0269-9370
Objective:To explore whether airway obstruction is associated with HIV in a cohort of HIV-infected and uninfected smokers.Methods:People living with HIV (PLWHIV) participated in the ANRS EP48 HIV CHEST study, an early lung cancer diagnosis study with low-dose chest tomography. HIV-uninfected study participants were from the CONSTANCES cohort. Inclusion criteria were an age greater than 40 years, a smoking history of at least 20 pack-years, and for PLWHIV, a CD4(+) T-lymphocyte nadir less than 350/l and last CD4(+) cell count more than 100 cells/l. Two randomly selected HIV-uninfected study participants were matched by age and sex with one PLWHIV. Prebronchodilatator forced expiratory volume in 1s (FEV1) to forced vital capacity (FVC) ratio was the primary outcome, and association of FEV1/FVC ratio less than 0.70 and FEV1 less than 80% of the theoretical value, as a proxy of chronic obstructive pulmonary disease, the secondary outcome.Results:In total, 351 PLWHIV and 702 HIV-uninfected study participants were included. Median age was 50 years, and 17% of study participants were women. Plasma HIV RNA was less than 50 copies/ml in 89% of PLWHIV, with a median CD4(+) cell count of 573 cells/l. HIV ( -2.19), age (per 10 years increase; -2.81), tobacco use (per 5 pack-years increase; -0.34), and hepatitis C virus serology (-2.50) were negatively associated with FEV1/FVC. HIV [odds ratio (OR: 1.72)], age (per 10 years increase; OR 1.77), and tobacco use (per 5 pack-years increase; OR 1.11) were significantly associated with the secondary outcome.Conclusion:Our study found a significant association of airway obstruction with HIV status in smokers aged more than 40 years with previous immunodeficiency.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
FRANCE
Localisation
Fonds IRD [F B010071930]
Identifiant IRD
fdi:010071930
