@article{fdi:010071914,
  title = {{F}laviviruses produce a subgenomic flaviviral {RNA} that enhances mosquito transmission},
  author = {{Y}eh, {S}. {C}. and {P}ompon, {J}ulien},
  editor = {},
  language = {{ENG}},
  abstract = {{M}osquito-borne flaviviruses ({MBFV}s) are a global public health burden. {MBFV}s have several unique 3{UTR} structures that inhibit the host {RNA} decay machinery to produce subgenomic flaviviral {RNA}s (sf{RNA}s). {N}umber of sf{RNA} species and their relative quantities are dependent on the 3{UTR} tertiary structures and can vary between tissues. {T}wo recent in vivo studies demonstrated that sf{RNA} enhances mosquito transmission, resulting in increased infection rate of saliva. {T}ransmission efficiency is determined by the immune response. {F}irst evidence points to sf{RNA} interference with the {T}oll and {RNA}i immune pathways. {H}owever, a more complex picture that includes flexibility in sf{RNA} production and interaction with immune-related proteins remains to be explored.},
  keywords = {flavivirus ; mosquitoes ; sf{RNA} ; innate immunity ; {X}rn1 ; transmission},
  booktitle = {},
  journal = {{DNA} and {C}ell {B}iology},
  volume = {37},
  numero = {3},
  pages = {[6 p.]},
  ISSN = {1044-5498},
  year = {2018},
  DOI = {10.1089/dna.2017.4059},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071914},
}