@article{fdi:010071905,
  title = {{T}ime to first positive {HIV}-1 {DNA} {PCR} may differ with antiretroviral regimen in infants infected with non-{B} subtype {HIV}-1},
  author = {{B}alasubramanian, {R}. and {F}owler, {M}. {G}. and {D}ominguez, {K}. and {L}ockman, {S}. and {T}ookey, {P}. {A}. and {H}uong, {N}. {N}. {G}. and {N}esheim, {S}. and {H}ughes, {M}. {D}. and {L}allemant, {M}arc and {T}osswill, {J}. and {S}haffer, {N}. and {S}herman, {G}. and {P}alumbo, {P}. and {S}hapiro, {D}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective: {T}o evaluate the association of type and timing of prophylactic maternal and infant antiretroviral regimen with time to first positive {HIV}-1 {DNA} {PCR} test, in nonbreastfed {HIV}-infected infants, from populations infected predominantly with {HIV}-1 non-{B} subtype virus. {D}esign: {A}nalysis of combined data on nonbreastfed {HIV}-infected infants from prospective cohorts in {B}otswana, {T}hailand, and the {U}nited {K}ingdom ({N} = 405). {M}ethods: {P}arametric models appropriate for interval-censored outcomes estimated the time to first positive {PCR} according to maternal or infant antiretroviral regimen category and timing of maternal antiretroviral initiation, with adjustment for covariates. {R}esults: {M}aternal antiretroviral regimens included: no antiretrovirals (n = 138), single-nucleoside analog reverse transcriptase inhibitor (n = 165), single-dose nevirapine with zidovudine (n = 66), and combination prophylaxis with 3 or more antiretrovirals [combination antiretroviral therapy (c{ART}), n = 36]. {T}ype of maternal/infant antiretroviral regimen and timing of maternal antiretroviral initiation were each significantly associated with time to first positive {PCR} (multivariate {P} < 0.0001). {T}he probability of a positive test with no antiretrovirals compared with the other regimen/timing groups was significantly lower at 1 day after birth, but did not differ significantly after age 14 days. {I}n a subgroup of 143 infants testing negative at birth, infant c{ART} was significantly associated with longer time to first positive test (multivariate {P} = 0.04). {C}onclusion: {T}ime to first positive {HIV}-1 {DNA} {PCR} in {HIV}-1-infected nonbreastfed infants (non-{B} {HIV} subtype) may differ according to maternal/infant antiretroviral regimen and may be longer with infant c{ART}, which may have implications for scheduling infant {HIV} {PCR}-diagnostic testing and confirming final infant {HIV} status.},
  keywords = {{DNA} {PCR} assays ; early infant diagnosis of {HIV} ; mother-to-child ; transmission of {HIV} ; {BOTSWANA} ; {THAILANDE} ; {ROYAUME} {UNI}},
  booktitle = {},
  journal = {{A}ids},
  volume = {31},
  numero = {18},
  pages = {2465--2474},
  ISSN = {0269-9370},
  year = {2017},
  DOI = {10.1097/qad.0000000000001640},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071905},
}