Edouard S., Subramanian G., Lefevre B., Dos Santos A., Pouedras P., Poinsignon Y., Mediannikov Oleg, Raoult Didier. (2013). Co-Infection with Arsenophonus nasoniae and Orientia tsutsugamushi in a traveler. Vector-Borne and Zoonotic Diseases, 13 (8), p. 565-571. ISSN 1530-3667.
Titre du document
Co-Infection with Arsenophonus nasoniae and Orientia tsutsugamushi in a traveler
Edouard S., Subramanian G., Lefevre B., Dos Santos A., Pouedras P., Poinsignon Y., Mediannikov Oleg, Raoult Didier
Source
Vector-Borne and Zoonotic Diseases, 2013,
13 (8), p. 565-571 ISSN 1530-3667
Here we report a case of co-infection with Orientia tsutsugamushi, the causative agent of scrub typhus, and Arsenophonus nasoniae in a woman with a rash and an eschar who returned from a trip to Southeast Asia. A. nasoniae was previously considered to be a secondary insect and tick endosymbiont of unknown pathogenicity in humans. We amplified both O. tsutsugamushi and A. nasoniae DNA from a skin eschar with qPCR, and a seroconversion for O. tsutsugamushi and A. nasoniae was observed with immunofluorescence assays and western blotting for this patient. And we used 2-D western blotting with an A. nasoniae antigen and polyclonal mouse anti-A. nasoniae antibodies produced in our laboratory to detect the specific antigenic A. nasoniae proteins.
