%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Lefevre, L.
%A Authier, H.
%A Stein, S.
%A Majorel, Clarisse
%A Couderc, B.
%A Dardenne, C.
%A Eddine, M. A.
%A Meunier, E.
%A Bernad, J.
%A Valentin, A.
%A Pipy, B.
%A Schoonjans, K.
%A Coste, A.
%T LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis
%D 2015
%L fdi:010071461
%G ENG
%J Nature Communications
%@ 2041-1723
%M ISI:000353702500041
%P art. 6801 [13 ]
%R 10.1038/ncomms7801
%U https://www.documentation.ird.fr/hor/fdi:010071461
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-02/010071461.pdf
%V 6
%W Horizon (IRD)
%X Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involving STAT6. We show that loss-of-function of LRH-1 in macrophages impedes IL-13-induced macrophage polarization due to impaired generation of 15-HETE PPAR gamma ligands. The incapacity to generate 15-HETE metabolites is at least partially caused by the compromised regulation of CYP1A1 and CYP1B1. Mice with LRH-1-deficient macrophages are, furthermore, highly susceptible to gastrointestinal and systemic Candida albicans infection. Altogether, these results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13-induced 15-HETE/PPAR gamma axis.
%$ 050