Publications des scientifiques de l'IRD

Lefevre L., Authier H., Stein S., Majorel Clarisse, Couderc B., Dardenne C., Eddine M. A., Meunier E., Bernad J., Valentin A., Pipy B., Schoonjans K., Coste A. (2015). LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis. Nature Communications, 6, p. art. 6801 [13 p.]. ISSN 2041-1723.

Titre du document
LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000353702500041
Auteurs
Lefevre L., Authier H., Stein S., Majorel Clarisse, Couderc B., Dardenne C., Eddine M. A., Meunier E., Bernad J., Valentin A., Pipy B., Schoonjans K., Coste A.
Source
Nature Communications, 2015, 6, p. art. 6801 [13 p.] ISSN 2041-1723
Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involving STAT6. We show that loss-of-function of LRH-1 in macrophages impedes IL-13-induced macrophage polarization due to impaired generation of 15-HETE PPAR gamma ligands. The incapacity to generate 15-HETE metabolites is at least partially caused by the compromised regulation of CYP1A1 and CYP1B1. Mice with LRH-1-deficient macrophages are, furthermore, highly susceptible to gastrointestinal and systemic Candida albicans infection. Altogether, these results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13-induced 15-HETE/PPAR gamma axis.
Plan de classement
Santé : généralités [050]
Localisation
Fonds IRD [F B010071461]
Identifiant IRD
fdi:010071461
Contact