@article{fdi:010071424,
  title = {{M}al{ERA} : an updated research agenda for characterising the reservoir and measuring transmission in malaria elimination and eradication},
  author = {{D}rakeley, {C}. and {N}oor, {A}. {M}. and {A}chee, {N}. {L}. and {B}ousema, {T}. and {C}ameron, {E}. and {D}omingo, {G}. and {E}isele, {T}. {P}. and {F}elger, {I}. and {G}ething, {P}. and {G}reenhouse, {B}. and {M}ueller, {I}. and {S}attabongkot, {J}. and {R}abinovich, {R}. and {V}olkman, {S}. and van den {H}oogen, {L}. and {A}de, {M}. {P}. and {B}assat, {Q}. and {B}ennett, {A}. and {C}ao, {J}. and {C}ohuet, {A}nna and {C}ox, {J}. and {C}unningham, {J}. and {D}issanayake, {G}. and {G}erardin, {J}. and {G}onzalez, {I}. and {H}amel, {M}. {J}. and {K}apulu, {M}. and {L}in, {O}. {A}. and {O}'{M}eara, {W}. {P}. and {M}alik, {E}. {M}. and {M}ayor, {A}. and {M}eshnick, {S}. and {M}oonen, {B}. and {Q}i, {G}. and {S}iqueira, {A}. {M}. and {S}later, {H}. and {T}ine, {R}. and {T}usting, {L}. and {W}u, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his paper summarises key advances in defining the infectious reservoir for malaria and the measurement of transmission for research and programmatic use since the {M}alaria {E}radication {R}esearch {A}genda (mal{ERA}) publication in 2011. {R}apid and effective progress towards elimination requires an improved understanding of the sources of transmission as well as those at risk of infection. {C}haracterising the transmission reservoir in different settings will enable the most appropriate choice, delivery, and evaluation of interventions. {S}ince 2011, progress has been made in a number of areas. {T}he extent of submicroscopic and asymptomatic infections is better understood, as are the biological parameters governing transmission of sexual stage parasites. {L}imitations of existing transmission measures have been documented, and proof-of-concept has been established for new innovative serological and molecular methods to better characterise transmission. {F}inally, there now exists a concerted effort towards the use of ensemble datasets across the spectrum of metrics, from passive and active sources, to develop more accurate risk maps of transmission. {T}hese can be used to better target interventions and effectively monitor progress toward elimination. {T}he success of interventions depends not only on the level of endemicity but also on how rapidly or recently an area has undergone changes in transmission. {I}mproved understanding of the biology of mosquito-human and human-mosquito transmission is needed particularly in low-endemic settings, where heterogeneity of infection is pronounced and local vector ecology is variable. {N}ew and improved measures of transmission need to be operationally feasible for the malaria programmes. {O}utputs from these research priorities should allow the development of a set of approaches (applicable to both research and control programmes) that address the unique challenges of measuring and monitoring transmission in near-elimination settings and defining the absence of transmission.},
  keywords = {},
  booktitle = {},
  journal = {{PLOS} {M}edicine},
  volume = {14},
  numero = {11},
  pages = {e1002452 [ p.]},
  ISSN = {1549-1676},
  year = {2017},
  DOI = {10.1371/journal.pmed.1002452},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071424},
}