@article{fdi:010071423,
  title = {{M}al{ERA} : un updated research agenda for insecticide and drug resistance in malaria elimination and eradication},
  author = {{C}hurcher, {T}. and {C}handa, {E}. and {C}oetzee, {M}. and {D}avenport, {M}. and {D}iabate, {A}. and {D}jimde, {A}. and {D}ondorp, {A}. {M}. and {D}onnelly, {M}. and {H}emingway, {J}. and {H}uijben, {S}. and {K}achur, {P}. and {K}amau, {E}. and {K}nox, {T}. {B}. and {L}obo, {N}. {F}. and {M}ayor, {A}. and {M}enard, {D}. and {P}aaijmans, {K}. and {P}icot, {S}. and {P}lowe, {C}. {V}. and {P}rice, {R}. and {R}abinovich, {R}. and {R}anson, {H}. and {R}eddy, {M}. and {R}ees, {S}. and {R}ingwald, {P}. and {R}abinovich, {R}. and {S}ibley, {C}. {H}. and {S}imard, {F}r{\'e}d{\'e}ric and {W}ondji, {C}. {S}. and {T}he mal{ERA} {R}efresh {C}onsultative {P}anel on {I}nsecticide and {D}rug {R}esistance},
  editor = {},
  language = {{ENG}},
  abstract = {{R}esistance to first-line treatments for {P}lasmodium falciparum malaria and the insecticides used for {A}nopheles vector control are threatening malaria elimination efforts. {S}uboptimal responses to drugs and insecticides are both spreading geographically and emerging independently and are being seen at increasing intensities. {W}hilst resistance is unavoidable, its effects can be mitigated through resistance management practices, such as exposing the parasite or vector to more than one selective agent. {R}esistance contributed to the failure of the 20th century {G}lobal {M}alaria {E}radication {P}rogramme, and yet the global response to this issue continues to be slow and poorly coordinated-too often, too little, too late. {T}he {M}alaria {E}radication {R}esearch {A}genda (mal{ERA}) {R}efresh process convened a panel on resistance of both insecticides and antimalarial drugs. {T}his paper outlines developments in the field over the past 5 years, highlights gaps in knowledge, and proposes a research agenda focused on managing resistance. {A} deeper understanding of the complex biological processes involved and how resistance is selected is needed, together with evidence of its public health impact. {R}esistance management will require improved use of entomological and parasitological data in decision making, and optimisation of the useful life of new and existing products through careful implementation, combination, and evaluation. {A} proactive, collaborative approach is needed from basic science and the development of new tools to programme and policy interventions that will ensure that the armamentarium of drugs and insecticides is sufficient to deal with the challenges of malaria control and its elimination.},
  keywords = {},
  booktitle = {},
  journal = {{PL}o{S} {M}edicine},
  volume = {14},
  numero = {11},
  pages = {e1002450 [16 p.]},
  ISSN = {1549-1676},
  year = {2017},
  DOI = {10.1371/journal.pmed.1002450},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071423},
}