@article{fdi:010071419,
  title = {{S}ustained high effectiveness of {R}ota{T}eq on hospitalizations attributable to rotavirus-associated gastroenteritis during 4 years in {F}inland},
  author = {{H}emming-{H}arlo, {M}. and {V}esikari, {T}. and {U}hari, {M}. and {R}enko, {M}. and {S}alminen, {M}. and {T}orcel-{P}agnon, {L}. and {H}artwig, {S}. and {S}imondon, {F}ran{\c{c}}ois and {B}ricout, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {R}otavirus vaccination with exclusive use of {R}ota{T}eq was added to the {N}ational {I}mmunization {P}rogramme ({NIP}) of {F}inland in {S}eptember 2009. {T}he objective of our study was to estimate the effectiveness and impact of {R}ota{T}eq after 4 years of follow-up. {M}ethods. {B}etween 2009 and 2013, we conducted a prospective surveillance study of children aged <16 years with acute gastroenteritis ({AGE}) and admitted in 2 hospitals in {F}inland. {R}otavirus and other gastroenteritis viruses were detected in stool samples by reverse-transcription polymerase chain reaction ({RT}-{PCR}) and enzyme-linked immunosorbent assays. {T}he effectiveness of {R}ota{T}eq was investigated by using a case-control design; wild-type rotavirus-positive children were classified as "cases" and rotavirus- negative children as "controls." {H}ospital discharge records were used to estimate the impact of {R}ota{T}eq on rotavirus-associated {AGE} ({RV}-{AGE}) and all-cause {AGE} ({AC}-{AGE}) hospitalizations of age-eligible children in the {NIP} by comparing the prevaccination (2001-2006) and post-{NIP} seasons (2009-2013). {R}esults. {T}he crude estimate of the effectiveness of {R}ota{T}eq to prevent {RV}-{AGE} hospitalization in {NIP} age-eligible children was 94.4% (95% confidence interval, 79.8%-98.4%). {N}o change in prevalent wild-type rotavirus genotypes was observed. {V}accinederived rotaviruses were detected in 8% of the children with {RV}-{AGE}, with a probable causal association in 2 children. {H}ospital discharge records revealed that {RV}-{AGE} and {AC}-{AGE} hospitalizations in children aged <16 years decreased in the two post-{NIP} seasons by 79% and 58%, respectively, compared to those in the prevaccination seasons. {C}onclusions. {O}ver 4 years of follow-up, high rotavirus vaccine coverage in the {NIP} (>95%) has led to a major reduction in {RV}-{AGE} and {AC}-{AGE} hospitalizations without a resurgence of rotavirus activity. {H}owever, rotavirus continues to circulate in older unvaccinated children.},
  keywords = {effectiveness ; gastroenteritis ; impact ; {R}ota{T}eq ; rotavirus ; vaccine ; {FINLANDE}},
  booktitle = {},
  journal = {{J}ournal of the {P}ediatric {I}nfectious {D}iseases {S}ociety},
  volume = {6},
  numero = {4},
  pages = {317--323},
  ISSN = {2048-7193},
  year = {2017},
  DOI = {10.1093/jpids/piw061},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071419},
}