Horizon / Plein textes La base de ressources documentaires de l'IRD

IRD

Publications des scientifiques de l'IRD

Salvadori Nicolas, Ngo-Giang-Huong Nicole, Duclercq C., Kanjanavanit S., Ngampiyaskul C., Techakunakorn P., Puangsombat A., Figoni J., Mary J. Y., Collins I. J., Cressey T. R., Le Coeur S., Sirirungsi W., Lallemant Marc, McIntosh K., Jourdain Gonzague. (2017). Incidence of tuberculosis and associated mortality in a cohort of human immunodeficiency virus-infected children initiating antiretroviral therapy. Journal of the Pediatric Infectious Diseases Society, 6 (2), 161-167. ISSN 2048-7193

Accès réservé (Intranet IRD) Document en accès réservé (Intranet IRD)

Lien direct chez l'éditeur doi:10.1093/jpids/piw090

Titre
Incidence of tuberculosis and associated mortality in a cohort of human immunodeficiency virus-infected children initiating antiretroviral therapy
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000416621100011
AuteursSalvadori Nicolas, Ngo-Giang-Huong Nicole, Duclercq C., Kanjanavanit S., Ngampiyaskul C., Techakunakorn P., Puangsombat A., Figoni J., Mary J. Y., Collins I. J., Cressey T. R., Le Coeur S., Sirirungsi W., Lallemant Marc, McIntosh K., Jourdain Gonzague.
SourceJournal of the Pediatric Infectious Diseases Society, 2017, 6 (2), p. 161-167. ISSN 2048-7193
RésuméBackground. We assessed the incidence of tuberculosis, risk factors for tuberculosis, and the contribution of tuberculosis on mortality in a large cohort of human immunodeficiency virus (HIV)-infected children <15 years of age initiating first-line antiretroviral therapy (ART) between 1999 and 2012 in Thailand, one of the 22 high tuberculosis burden countries. Methods. A physician reviewed and classified tuberculosis cases. Incidence was the number of children with incident tuberculosis, defined as a first or recurrent tuberculosis diagnosis >30 days after ART initiation, divided by the total person-years of follow-up (PYFU). Risk factors for incident tuberculosis were identified using Fine and Gray's competing risks models, with death from other causes treated as a competing event, and risk factors for death were identified using Cox models. Results. At ART initiation, 670 children (55% female) had a median age of 6.4 years (interquartile range, 2.0-9.6), body mass index-for-age z-score -0.8 (-1.9 to 0.0), HIV ribonucleic acid viral load 5.1 log(10) copies/mL (4.6-5.6), and CD4 9% (3-17). Median duration of follow-up was 7.7 years. Tuberculosis incidence was 7 per 1000 PYFU (95% confidence interval [CI], 5-11) and decreased with ART duration. Lower age-adjusted hemoglobin, hematocrit, and CD4 at ART initiation were associated with a higher risk of incident tuberculosis. Of the 30 incident tuberculosis cases, 9 died. Diagnosis of incident tuberculosis was associated with mortality (unadjusted hazard ratio = 10.2, 95% CI = 4.8-21.5, P<.001 and adjusted hazard ratio = 5.4, 95% CI = 2.5-11.7, P<.001). Conclusions. Incident tuberculosis was strongly associated with mortality. CD4 counts or hemoglobin or hematocrit levels may prompt clinicians to consider a possible tuberculosis infection.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050]
Descr. géo.THAILANDE
LocalisationFonds IRD [F B010071418]
Identifiant IRDfdi:010071418
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010071418

Export des données

Disponibilité des documents

Télechargment fichier PDF téléchargeable

Lien sur le Web lien chez l'éditeur

Accès réservé en accès réservé

HAL en libre accès sur HAL


Accès aux documents originaux :

Accès direct

Bureau du chercheur

Site de la documentation

Espace intranet IST (accès réservé)

Suivi des publications IRD (accès réservé)

Mentions légales

Services Horizon

Poser une question

Consulter l'aide en ligne

Déposer une publication (accès réservé)

S'abonner au flux RSS

Voir les tableaux chronologiques et thématiques

Centres de documentation

Bondy

Montpellier (centre IRD)

Montpellier (MSE)

Nouméa

Papeete

Niamey

Ouagadougou

Tunis

La Paz

Quito