Human Immunodeficiency Virus (HIV) drug resistance in African infants and young children newly diagnosed with HIV : a multicountry analysis - fdi:010071412 - Horizon

Horizon / Plein textes La base de ressources documentaires de l'IRD

IRD

Publications des scientifiques de l'IRD

Jordan M. R., Penazzato M., Cournil Amandine, Vubil A., Jani I., Hunt G., Carmona S., Maphalala G., Mthethwa N., Watera C., Kaleebu P., Musanhu C. C., Mtapuri-Zinyowera S., Dzangare J., Peeters Martine, Yang C. F., Parkin N., Bertagnolio S. (2017). Human Immunodeficiency Virus (HIV) drug resistance in African infants and young children newly diagnosed with HIV : a multicountry analysis. Clinical Infectious Diseases, 65 (12), 2018-2025. ISSN 1058-4838

Accès réservé (Intranet IRD) Document en accès réservé (Intranet IRD)

Lien direct chez l'éditeur doi:10.1093/cid/cix698

Titre
Human Immunodeficiency Virus (HIV) drug resistance in African infants and young children newly diagnosed with HIV : a multicountry analysis
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000416494500009
AuteursJordan M. R., Penazzato M., Cournil Amandine, Vubil A., Jani I., Hunt G., Carmona S., Maphalala G., Mthethwa N., Watera C., Kaleebu P., Musanhu C. C., Mtapuri-Zinyowera S., Dzangare J., Peeters Martine, Yang C. F., Parkin N., Bertagnolio S.
SourceClinical Infectious Diseases, 2017, 65 (12), p. 2018-2025. ISSN 1058-4838
RésuméBackground. Programs for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) have been scaled up in many low-and middle-income countries. However, HIV drug resistance (HIVDR) data among HIV-1-infected young children remain limited. Methods. Surveys of pretreatment HIVDR among children aged < 18 months who were diagnosed with HIV through early infant diagnosis were conducted in 5 sub-Saharan African countries (Mozambique, Swaziland, South Africa, Uganda, and Zimbabwe) between 2011 and 2014 following World Health Organization (WHO) guidance. Deidentified demographic and clinical data were used to explore risk factors associated with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance. Results. Among the 1450 genotypes analyzed, 1048 had accompanying demographic and clinical data. The median age of children was 4 months; 50.4% were female. HIV from 54.1% showed resistance to 1 or more antiretroviral (ARV) drugs, with 53.0% and 8.8% having resistance to 1 or more NNRTI or nucleoside reverse transcriptase inhibitors, respectively. NNRTI resistance was particularly high in children exposed to ARV drugs through PMTCT; adjusted odds ratios were 1.8 (95% confidence interval [CI], 1.3-2.6) for maternal exposure only and 2.4 (CI, 1.6-3.6) for neonatal exposure only. Conclusions. Protease inhibitor-based regimens in children aged < 3 years are currently recommended by WHO, but the implementation of this recommendation is suboptimal. These results reinforce the urgent need to overcome barriers to scaling up pediatric protease inhibitor-based regimens in sub-Saharan Africa and underscore the need to accelerate the study and approval of integrase inhibitors for use in young children.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050] ; Sciences fondamentales / Techniques d'analyse et de recherche [020]
Descr. géo.AFRIQUE SUBSAHARIENNE ; MOZAMBIQUE ; SWAZILAND ; AFRIQUE DU SUD ; OUGANDA ; ZIMBABWE
LocalisationFonds IRD [F B010071412]
Identifiant IRDfdi:010071412
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010071412

Export des données

Disponibilité des documents

Télechargment fichier PDF téléchargeable

Lien sur le Web lien chez l'éditeur

Accès réservé en accès réservé

HAL en libre accès sur HAL


Accès aux documents originaux :

Le FDI est labellisé CollEx

Accès direct

Bureau du chercheur

Site de la documentation

Espace intranet IST (accès réservé)

Suivi des publications IRD (accès réservé)

Mentions légales

Services Horizon

Poser une question

Consulter l'aide en ligne

Déposer une publication (accès réservé)

S'abonner au flux RSS

Voir les tableaux chronologiques et thématiques

Centres de documentation

Bondy

Montpellier (centre IRD)

Montpellier (MSE)

Nouméa

Papeete

Niamey

Ouagadougou

Tunis

La Paz

Quito