@article{fdi:010071381,
  title = {{PFI}1785w : a highly conserved protein associated with pregnancy associated malaria},
  author = {{K}amaliddin, {C}. and {S}alnot, {V}. and {L}educ, {M}. and {E}zinmegnon, {S}. and {B}roussard, {C}. and {F}ievet, {N}adine and {D}eloron, {P}hilippe and {G}uillonneau, {F}. and {B}ertin, {G}wladys},
  editor = {},
  language = {{ENG}},
  abstract = {{P}regnancy-associated malaria ({PAM}) is one of the severe forms of {P}lasmodium falciparum infection. {T}he main antigen {VAR}2{CSA} is the target of vaccine development. {H}owever, the large size of {VAR}2{CSA} protein and its high degree of variability limit to the efficiency of the vaccination. {U}sing quantitative mass spectrometry method, we detected and quantified proteotypic peptides from 5 predicted {PAM} associated proteins. {O}ur results confirmed that {PFI}1785w is over-expressed in {PAM} samples. {T}hen, we investigated {PFI}1785w variability among a set of parasite samples from various endemic areas. {PFI}1785w appear to be more conserved than {VAR}2{CSA}. {PFB}0115w, another {PAM} associated protein, seems also associated with the pathology. {F}urther vaccination strategies could integrate other proteins in addition to the major {VAR}2{CSA} antigen to improve immune response to vaccination.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {12},
  numero = {11},
  pages = {e0187817 [12 p.]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0187817},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071381},
}