@article{fdi:010071363,
  title = {{TDF} and quantitative ultrasound bone quality in {A}frican patients on second line {ART}, {ANRS} 12169 2{LADY} sub-study},
  author = {{K}abore, {F}. {N}. and {E}ymard-{D}uvernay, {S}abrina and {Z}oungrana, {J}. and {B}adiou, {S}. and {B}ado, {G}. and {H}ema, {A}. and {D}iouf, {A}. and {D}elaporte, {E}. and {K}oulla-{S}hiro, {S}. and {C}iaffi, {L}. and {C}ournil, {A}mandine},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {B}one demineralization, which leads to osteoporosis and increased fracture risk, is a common metabolic disorder in {HIV}-infected individuals. {I}n this study, we aimed to assess the change in bone quality using quantitative ultrasound ({QUS}) over 96 weeks of follow-up after initiation of second-line treatment, and to identify factors associated with change in bone quality. {M}ethods and findings {I}n a randomized trial ({ANRS} 12169), {TDF} and {PI}-na ve participants failing standard first-line treatment, from {B}urkina {F}aso, {C}ameroon, and {S}enegal were randomized to receive either {TDF}/{FTC}/{LPV}r, {ABC}/ddl/{LPV}r or {TDF}/{FTC}/{DRV}r. {T}heir bone quality was assessed using calcaneal {QUS} at baseline and every 24 weeks until week 96. {S}tiffness index ({SI}) was used to measure bone quality. {O}ut of 228 participants, 168 (74%) were women. {A}t baseline, median age was 37 years ({IQR}: 33-46 years) and median {T}-{CD}4 count was 199 cells/mu l ({IQR}: 113-319 cells/mu l). {T}he median duration of first-line antiretroviral treatment ({ART}) was 52 months ({IQR}: 36-72 months) and the median baseline {SI} was 101 ({IQR}: 87-116). {I}n multivariable analysis, factors associated with baseline {SI} were sex ([beta = -10.8 [-18.1,-3.5] for women), age ([beta = -8.7 [-12.4,-5.1] per 10 years), body mass index ({BMI}) ((beta = +0.8 [0.1,1.5] per unit of {BMI}), and study site ((beta = +12.8 [6.5,19.1] for {C}ameroon). {A}fter 96 weeks of second-line therapy, a reduction of 7.1% in mean {SI} was observed, as compared with baseline. {F}actors associated with {SI} during the follow-up were similar to those found at baseline. {E}xposure to {TDF} was not associated with a greater loss of bone quality over time. {C}onclusion {B}one quality decreased after second-line {ART} initiation in {A}frican patients independently of {TDF} exposure. {F}actors associated with bone quality include age, sex, baseline {BMI}, study site, and duration of follow-up.},
  keywords = {{BURKINA} {FASO} ; {SENEGAL} ; {CAMEROUN} ; {BOBO} {DIOULASSO} ; {DAKAR} ; {YAOUNDE}},
  booktitle = {},
  journal = {{PLOS} {O}ne},
  volume = {12},
  numero = {},
  pages = {art. 11 [14 ]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0186686},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071363},
}