@article{fdi:010071342,
  title = {{T}he study of trypanosome species circulating in domestic animals in two human {A}frican trypanosomiasis foci of {C}ote d'{I}voire identifies pigs and cattle as potential reservoirs of {T}rypanosoma brucei gambiense},
  author = {{N}'{D}jetchi, {M}. {K}. and {I}lboudo, {H}. and {K}offi, {M}. and {K}abore, {J}. and {K}abore, {J}. {W}. and {K}aba, {D}. and {C}ourtin, {F}abrice and {C}oulibaly, {B}. and {F}auret, {P}ierre and {K}ouakou, {L}. {A}. and {R}avel, {S}ophie and {D}eborggraeve, {S}. and {S}olano, {P}hilippe and {D}e {M}eeûs, {T}hierry and {B}ucheton, {B}runo and {J}amonneau, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {I}mportant control efforts have led to a significant reduction of the prevalence of human {A}frican trypanosomiasis ({HAT}) in {C}ote d'{I}voire, but the disease is still present in several foci. {T}he existence of an animal reservoir of {T}rypanosoma brucei gambiense may explain disease persistence in these foci where animal breeding is an important source of income but where the prevalence of animal {A}frican trypanosomiasis ({AAT}) is unknown. {T}he aim of this study was to identify the trypanosome species circulating in domestic animals in both {B}onon and {S}infra {HAT} endemic foci. {M}ethodology/{P}rincipal findings 552 domestic animals (goats, pigs, cattle and sheep) were included. {B}lood samples were tested for trypanosomes by microscopic observation, species-specific {PCR} for {T}. brucei sl, {T}. congolense, {T}. vivax and subspecies-specific {PCR} for {T}. b. gambiense and {T}. b. gambiense immune trypanolysis ({TL}). {I}nfection rates varied significantly between animal species and were by far the highest in pigs (30%). {T}. brucei s. l was the most prevalent trypanosome species (13.7%) followed by {T}. congolense. {N}o {T}. b. gambiense was identified by {PCR} while high {TL} positivity rates were observed using {T}. b. gambiense specific variants (up to 27.6% for pigs in the {B}onon focus). {C}onclusion {T}his study shows that domestic animals are highly infected by trypanosomes in the studied foci. {T}his was particularly true for pigs, possibly due to a higher exposure of these animals to tsetse flies. {W}hereas {T}. brucei s.l. was the most prevalent species, discordant results were obtained between {PCR} and {TL} regarding {T}. b. gambiense identification. {I}t is therefore crucial to develop better tools to study the epidemiological role of potential animal reservoir for {T}. b. gambiense. {O}ur study illustrates the importance of "one health" approaches to reach {HAT} elimination and contribute to {AAT} control in the studied foci.},
  keywords = {{COTE} {D}'{IVOIRE}},
  booktitle = {},
  journal = {{PLOS} {N}eglected {T}ropical {D}iseases},
  volume = {11},
  numero = {10},
  pages = {e0005993 [16 p.]},
  ISSN = {1935-2735},
  year = {2017},
  DOI = {10.1371/journal.pntd.0005993},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071342},
}