N'Djetchi M. K., Ilboudo H., Koffi M., Kabore J., Kabore J. W., Kaba D., Courtin Fabrice, Coulibaly B., Fauret Pierre, Kouakou L. A., Ravel Sophie, Deborggraeve S., Solano Philippe, De Meeûs Thierry, Bucheton Bruno, Jamonneau Vincent. (2017). The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Cote d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense. PLOS Neglected Tropical Diseases, 11 (10), p. e0005993 [16 p.]. ISSN 1935-2735.
Titre du document
The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Cote d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense
Année de publication
2017
Auteurs
N'Djetchi M. K., Ilboudo H., Koffi M., Kabore J., Kabore J. W., Kaba D., Courtin Fabrice, Coulibaly B., Fauret Pierre, Kouakou L. A., Ravel Sophie, Deborggraeve S., Solano Philippe, De Meeûs Thierry, Bucheton Bruno, Jamonneau Vincent
Source
PLOS Neglected Tropical Diseases, 2017,
11 (10), p. e0005993 [16 p.] ISSN 1935-2735
Background Important control efforts have led to a significant reduction of the prevalence of human African trypanosomiasis (HAT) in Cote d'Ivoire, but the disease is still present in several foci. The existence of an animal reservoir of Trypanosoma brucei gambiense may explain disease persistence in these foci where animal breeding is an important source of income but where the prevalence of animal African trypanosomiasis (AAT) is unknown. The aim of this study was to identify the trypanosome species circulating in domestic animals in both Bonon and Sinfra HAT endemic foci. Methodology/Principal findings 552 domestic animals (goats, pigs, cattle and sheep) were included. Blood samples were tested for trypanosomes by microscopic observation, species-specific PCR for T. brucei sl, T. congolense, T. vivax and subspecies-specific PCR for T. b. gambiense and T. b. gambiense immune trypanolysis (TL). Infection rates varied significantly between animal species and were by far the highest in pigs (30%). T. brucei s. l was the most prevalent trypanosome species (13.7%) followed by T. congolense. No T. b. gambiense was identified by PCR while high TL positivity rates were observed using T. b. gambiense specific variants (up to 27.6% for pigs in the Bonon focus). Conclusion This study shows that domestic animals are highly infected by trypanosomes in the studied foci. This was particularly true for pigs, possibly due to a higher exposure of these animals to tsetse flies. Whereas T. brucei s.l. was the most prevalent species, discordant results were obtained between PCR and TL regarding T. b. gambiense identification. It is therefore crucial to develop better tools to study the epidemiological role of potential animal reservoir for T. b. gambiense. Our study illustrates the importance of "one health" approaches to reach HAT elimination and contribute to AAT control in the studied foci.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde animal [080]
Description Géographique
COTE D'IVOIRE
Localisation
Fonds IRD [F B010071342]
Identifiant IRD
fdi:010071342
