Horizon / Plein textes La base de ressources documentaires de l'IRD

IRD

 

Publications des scientifiques de l'IRD

Ahouty B., Koffi M., Ilboudo H., Simo G., Matovu E., Mulindwa J., Hertz-Fowler C., Bucheton Bruno, Sidibe I., Jamonneau Vincent, MacLeod A., Noyes H., N'Guetta S. P., TrypanoGEN Research Group H3Africa Consortium. (2017). Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Cote d'Ivoire. PLOS Neglected Tropical Diseases, 11 (10), e0005992 [13 p.]. ISSN 1935-2735

Fichier PDF disponiblehttp://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-11/010071341.pdf[ PDF Link ]

Lien direct chez l'éditeur doi:10.1371/journal.pntd.0005992

Titre
Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Cote d'Ivoire
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000414271400050
AuteursAhouty B., Koffi M., Ilboudo H., Simo G., Matovu E., Mulindwa J., Hertz-Fowler C., Bucheton Bruno, Sidibe I., Jamonneau Vincent, MacLeod A., Noyes H., N'Guetta S. P., TrypanoGEN Research Group H3Africa Consortium.
SourcePLOS Neglected Tropical Diseases, 2017, 11 (10), p. e0005992 [13 p.]. p. e0005992 [13 p.] ISSN 1935-2735
RésuméHuman African Trypanosomiasis (HAT) or sleeping sickness is a Neglected Tropical Disease. Long regarded as an invariably fatal disease, there is increasing evidence that infection by T.b. gambiense can result in a wide range of clinical outcomes, including latent infections, which are long lasting infections with no parasites detectable by microscopy. The determinants of this clinical diversity are not well understood but could be due in part to parasite or host genetic diversity in multiple genes, or their interactions. A candidate gene association study was conducted in Cote d'Ivoire using a case-control design which included a total of 233 subjects (100 active HAT cases, 100 controls and 33 latent infections). All three possible pairwise comparisons between the three phenotypes were tested using 96 SNPs in 16 candidate genes (IL1, IL4, IL4R, IL6, IL8, IL10, IL12, IL12R, TNFA, INFG, MIF, APOL1, HPR, CFH, HLA-A and HLA-G). Data from 77 SNPs passed quality control. There were suggestive associations at three loci in IL6 and TNFA in the comparison between active cases and controls, one SNP in each of APOL1, MIF and IL6 in the comparison between latent infections and active cases and seven SNP in IL4, HLA-G and TNFA between latent infections and controls. No associations remained significant after Bonferroni correction, but the Benjamini Hochberg false discovery rate test indicated that there were strong probabilities that at least some of the associations were genuine. The excess of associations with latent infections despite the small number of samples available suggests that these subjects form a distinct genetic cluster different from active HAT cases and controls, although no clustering by phenotype was observed by principle component analysis. This underlines the complexity of the interactions existing between host genetic polymorphisms and parasite diversity.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050]
Descr. géo.COTE D'IVOIRE
LocalisationFonds IRD [F B010071341]
Identifiant IRDfdi:010071341
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010071341

Export des données

Disponibilité des documents

Télechargment fichier PDF téléchargeable

Lien sur le Web lien chez l'éditeur

Accès réservé en accès réservé

HAL en libre accès sur HAL


* PDF Link :

    à télécharger pour citer/partager ce document sur les réseaux sociaux académiques


Accès aux documents originaux :

Le FDI est labellisé CollEx

Accès direct

Bureau du chercheur

Site de la documentation

Espace intranet IST (accès réservé)

Suivi des publications IRD (accès réservé)

Mentions légales

Services Horizon

Poser une question

Consulter l'aide en ligne

Déposer une publication (accès réservé)

S'abonner au flux RSS

Voir les tableaux chronologiques et thématiques

Centres de documentation

Bondy

Montpellier (centre IRD)

Montpellier (MSE)

Cayenne

Nouméa

Papeete

Abidjan

Dakar

Niamey

Ouagadougou

Tunis

La Paz

Quito