@article{fdi:010071225,
  title = {{E}volution in fecal bacterial/viral composition in infants of two central {A}frican countries ({G}abon and {R}epublic of the {C}ongo) during their first month of life},
  author = {{B}razier, {L}. and {E}lguero, {E}ric and {K}oumavor, {C}. {K}. and {R}enaud, {N}. and {P}rugnolle, {F}ranck and {T}homas, {F}. and {A}tegbo, {S}. and {E}ngoba, {M}. and {O}bengui, and {L}eroy, {E}ric and {D}urand, {P}. and {R}enaud, {F}. and {B}ecquart, {P}ierre},
  editor = {},
  language = {{ENG}},
  abstract = {{F}ew studies have analyzed the gut microbiota of child in unindustrialized countries, but none during the first month of life. {S}tool samples were collected from healthy newborns in hospitals of {G}abon (n = 6) and {R}epublic of the {C}ongo (n = 9) at different time points during the first month of life: meconium, day 2 ({D}02), day 7 ({D}07) and day 28 ({D}28). {I}n addition, one fecal sample was collected from each mother after delivery. {M}etagenomic sequencing was performed to determine the bacterial communities, and multiplex real-time {PCR} was used to detect the presence of seven enteric viruses (rotavirus a, adenovirus, norovirus {I} and {II}, sapovirus, astrovirus, enterovirus) in these samples. {B}acterial diversity was high in the first days of life, and was dominated by the genus {P}revotella. {T}hen, it rapidly decreased and remained low up to {D}28 when the gut flora was composed almost exclusively of strictly anaerobic bacteria. {E}ach infant's fecal bacterial microbiota composition was significantly closer to that of their mother than to that of any other woman in the mothers' group, suggesting an intrauterine, placental or amniotic fluid origin of such bacteria. {M}oreover, bacterial communities differed according to the delivery mode. {O}verall, the bacterial microbiota communities displayed a similar diversification and expansion in newborns within and between countries during the first four weeks of life. {M}oreover, six of the fifteen infants of this study harbored enteric viruses (rotavirus, enterovirus and adenovirus) in fecal samples, but never in the meconium. {A} maternal source for the viruses detected at {D}02 and {D}07 can be excluded because none of them was found also in the child's mother. {T}hese findings improve our knowledge on the gut bacterial and viral communities of infants from two {S}ub-{S}aharan countries during their first month of life.},
  keywords = {{GABON} ; {CONGO} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{PLOS} {O}ne},
  volume = {12},
  numero = {10},
  pages = {e0185569 [19 p.]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0185569},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071225},
}