@article{fdi:010071222,
  title = {{A} multi-center field study of two point-of-care tests for circulating {W}uchereria bancrofti antigenemia in {A}frica},
  author = {{C}hesnais, {C}{\'e}dric and {A}waca-{U}von, {N}. {P}. and {B}olay, {F}. {K}. and {B}oussinesq, {M}ichel and {F}ischer, {P}. {U}. and {G}ankpala, {L}. and {M}eite, {A}. and {M}issamou, {F}. and {P}ion, {S}{\'e}bastien and {W}eil, {G}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {T}he {G}lobal {P}rogramme to {E}liminate {L}ymphatic {F}ilariasis uses point-of-care tests for circulating filarial antigenemia ({CFA}) to map endemic areas and for monitoring and evaluating the success of mass drug administration ({MDA}) programs. {W}e compared the performance of the reference {B}inax{NOW} {F}ilariasis card test ({ICT}, introduced in 1997) with the {A}lere {F}ilariasis {T}est {S}trip ({FTS}, introduced in 2013) in 5 endemic study sites in {A}frica. {M}ethodology {T}he tests were compared prior to {MDA} in two study sites ({C}ongo and {C}ote d'{I}voire) and in three sites that had received {MDA} ({DRC} and 2 sites in {L}iberia). {D}ata were analyzed with regard to% positivity, % agreement, and heterogeneity. {M}odels evaluated potential effects of age, gender, and blood microfilaria ({M}f) counts in individuals and effects of endemicity and history of {MDA} at the village level as potential factors linked to higher sensitivity of the {FTS}. {L}astly, we assessed relationships between {CFA} scores and {M}f in pre- and post-{MDA} settings. {P}rincipal findings {P}aired test results were available for 3,682 individuals. {A}ntigenemia rates were 8% and 22% higher by {FTS} than by {ICT} in pre-{MDA} and in post-{MDA} sites, respectively. {FTS}/{ICT} ratios were higher in areas with low infection rates. {T}he probability of having microfilaremia was much higher in persons with {CFA} scores >1 in untreated areas. {H}owever, this was not true in post-{MDA} settings. {C}onclusions/{S}ignificance {T}his study has provided extensive new information on the performance of the {FTS} compared to {ICT} in {A}frica and it has confirmed the increased sensitivity of {FTS} reported in prior studies. {V}ariability in {FTS}/{ICT} was related in part to endemicity level, history of {MDA}, and perhaps to the medications used for {MDA}. {T}hese results suggest that {FTS} should be superior to {ICT} for mapping, for transmission assessment surveys, and for post-{MDA} surveillance.},
  keywords = {{CONGO} ; {COTE} {D}'{IVOIRE} ; {LIBERIA} ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{PLOS} {N}eglected {T}ropical {D}iseases},
  volume = {11},
  numero = {9},
  pages = {e0005703 [15 p.]},
  ISSN = {1935-2735},
  year = {2017},
  DOI = {10.1371/journal.pntd.0005703},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071222},
}