@article{fdi:010071057,
  title = {{C}andidate gene polymorphisms study between human {A}frican trypanosomiasis clinical phenotypes in {G}uinea},
  author = {{K}abore, {J}. {W}. and {I}lboudo, {H}. and {N}oyes, {H}. and {C}amara, {O}. and {K}abore, {J}. and {C}amara, {M}. and {K}offi, {M}. and {L}ejon, {V}eerle and {J}amonneau, {V}incent and {M}ac{L}eod, {A}. and {H}ertz-{F}owler, {C}. and {M}arie, {A}. and {B}elem, {G}. and {M}atovu, {E}. and {B}ucheton, {B}runo and {S}idibe, {I}. and {T}rypano, {G}. {E}. {N}. {R}es {G}rp},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {H}uman {A}frican trypanosomiasis ({HAT}), a lethal disease induced by {T}rypanosoma brucei gambiense, has a range of clinical outcomes in its human host in {W}est {A}frica: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals able to regulate parasitaemia at very low levels, have all been reported from endemic foci. {I}n order to test if this clinical diversity is influenced by host genetic determinants, the association between candidate gene polymorphisms and {HAT} outcome was investigated in populations from {HAT} active foci in {G}uinea. {M}ethodology and results {S}amples were collected from 425 individuals; comprising of 232 {HAT} cases, 79 subjects with long lasting positive and specific serology but negative parasitology and 114 endemic controls. {G}enotypes of 28 {SNP}s in eight genes passed quality control and were used for an association analysis. {IL}6 rs1818879 allele {A} (p = 0.0001, {OR} = 0.39, {CI}95 = [0.24-0.63], {BONF} = 0.0034) was associated with a lower risk of progressing from latent infection to active disease. {MIF} rs36086171 allele {G} seemed to be associated with an increased risk (p = 0.0239, {OR} = 1.65, {CI}95 = [1.07-2.53], {BONF} = 0.6697) but did not remain significant after {B}onferroni correction. {S}imilarly {MIF} rs12483859 {C} allele seems be associated with latent infections (p = 0.0077, {OR} = 1.86, {CI}95 = [1.18-2.95], {BONF} = 0.2157). {W}e confirmed earlier observations that {APOL}1 {G}2 allele ({DEL}) (p = 0.0011, {OR} = 2.70, {CI}95 = [1.49-4.91], {BONF} = 0.0301) is associated with a higher risk and {APOL}1 {G}1 polymorphism (p = 0.0005, {OR} = 0.45, {CI}95 = [0.29-0.70], {BONF} = 0.0129) with a lower risk of developing {HAT}. {N}o associations were found with other candidate genes. {C}onclusion {O}ur data show that host genes are involved in modulating {T}rypanosoma brucei gambiense infection outcome in infected individuals from {G}uinea with {IL}6 rs1818879 being associated with a lower risk of progressing to active {HAT}. {T}hese results enhance our understanding of host-parasite interactions and, ultimately, may lead to the development of new control tools.},
  keywords = {{GUINEE}},
  booktitle = {},
  journal = {{PLOS} {N}eglected {T}ropical {D}iseases},
  volume = {11},
  numero = {8},
  pages = {e0005833 [13 p.]},
  ISSN = {1935-2735},
  year = {2017},
  DOI = {10.1371/journal.pntd.0005833},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071057},
}