@article{fdi:010071028,
  title = {{N}on-cell-autonomous effects yield lower clonal diversity in expanding tumors},
  author = {{T}issot, {T}. and {T}homas, {F}. and {R}oche, {B}enjamin},
  editor = {},
  language = {{ENG}},
  abstract = {{R}ecent cancer research has investigated the possibility that non-cell-autonomous ({NCA}) driving tumor growth can support clonal diversity ({CD}). {I}ndeed, mutations can affect the phenotypes not only of their carriers ("cell-autonomous", {CA} effects), but also sometimes of other cells ({NCA} effects). {H}owever, models that have investigated this phenomenon have only considered a restricted number of clones. {H}ere, we designed an individual-based model of tumor evolution, where clones grow and mutate to yield new clones, among which a given frequency have {NCA} effects on other clones' growth. {U}nlike previously observed for smaller assemblages, most of our simulations yield lower {CD} with high frequency of mutations with {NCA} effects. {O}wing to {NCA} effects increasing competition in the tumor, clones being already dominant are more likely to stay dominant, and emergent clones not to thrive. {T}hese results may help personalized medicine to predict intratumor heterogeneity across different cancer types for which frequency of {NCA} effects could be quantified.},
  keywords = {},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {7},
  numero = {},
  pages = {art. 11157 [11 p.]},
  ISSN = {2045-2322},
  year = {2017},
  DOI = {10.1038/s41598-017-11562-w},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071028},
}