@article{fdi:010071017,
  title = {{M}olecular epidemiology of malaria in {C}ameroon and {C}ote d'{I}voire. {XXXI}. {K}elch 13 propeller sequences in {P}lasmodium falciparum isolates before and after implementation of artemisinin-based combination therapy},
  author = {{D}jaman, {J}. {A}. and {O}lefongo, {D}. and {A}ko, {A}. {B}. and {R}oman, {J}ocelyne and {N}gane, {V}. {F}. and {B}asco, {L}eonardo and {T}ahar, {R}achida},
  editor = {},
  language = {{ENG}},
  abstract = {{A}rtemisinin-resistant malaria has not been reported from {A}frica, but resistance can possibly spread from {A}sia or arise independently in {A}frica. {T}he emergence of artemisinin resistance in {A}frica can be monitored by molecular assay of {K}elch 13 ({K}13) propeller sequences. {A} total of 251 archived {DNA} samples of {P}lasmodium falciparum isolates collected in 2002, 2003, and 2006 in {Y}aounde, {C}ameroon, and 47 samples collected in 2006 and 2013 in {A}bidjan, {C}ote d'{I}voire, were analyzed for {K}13-propeller sequence polymorphism. {O}nly one isolate carried a mutant {K}13-propeller allele ({E}602{D}). {N}one of the isolates carried the key mutant alleles ({Y}493{H}, {R}539{T}, {I}543{T}, and {C}580{Y}) associated with artemisinin resistance in {C}ambodia. {T}he presence of the mutant allele was not correlated with in vitro response to dihydroartemisinin determined by the classical hypoxanthine incorporation assay. {T}here was no evidence of {K}13 mutations associated with artemisinin resistance before and soon after the introduction of artemisinin-based combination therapies in {C}ameroon and {C}ote d'{I}voire.},
  keywords = {{CAMEROUN} ; {COTE} {D}'{IVOIRE} ; {CAMBODGE}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {97},
  numero = {1},
  pages = {222--224},
  ISSN = {0002-9637},
  year = {2017},
  DOI = {10.4269/ajtmh.16-0889},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071017},
}