@article{fdi:010071002,
  title = {{A}dherence, tolerability, and outcome after 36 months of isoniazid-preventive therapy in 2 rural clinics of {S}waziland {A} prospective observational feasibility study},
  author = {{M}ueller, {Y}. and {M}pala, {Q}. and {K}erschberger, {B}. and {R}usch, {B}. and {M}c{H}unu, {G}. and {M}azibuko, {S}. and {B}onnet, {M}aryline},
  editor = {},
  language = {{ENG}},
  abstract = {{A}lthough efficacy of 36 months isoniazid preventive therapy ({IPT}) among {HIV}-positive individuals has been proven in trial settings, outcome, tolerance, and adherence have rarely been evaluated in real-life settings. {T}his is a prospective observational cohort study conducted in 2 primary care rural clinics in {S}waziland. {A}fter negative tuberculosis symptom screening, patients either with the positive tuberculin skin test ({TST}) or after tuberculosis treatment were initiated on {IPT} for 144 weeks. {I}n addition to routine clinic visits, adherence was assessed every semester. {O}f 288 eligible patients, 2 patients never started {IPT} (1 refusal, 1 contraindication), and 253 (87.8%), 234 (81.3%), and 228 (79.2%) were still on {IPT} after 48, 96, and 144 weeks, respectively (chi(2){P}=. 01). {O}f 41 patients who interrupted {IPT} before 144 weeks, 21 defaulted (of which 17 also defaulted {HIV} care); 16 stopped because of adverse drug reactions; 2 were discontinued by clinicians' mistake and 1 because of {TB} symptoms. {F}ive patients (1.7%) died of causes not related to {IPT}, 5 (1.7%) developed {TB} of which 2 were isoniazid-resistant, and 9 (3.1%) were transferred to another clinic. {A}s an indicator of adherence, isoniazid could be detected in the urine during 86.3% (302/350) and 73.6% (248/337) of patient visits in the 2 clinics, respectively (chi(2){P}<. 001). {T}he routine implementation of {IPT} 36 months was feasible and good patient outcomes were achieved, with low {TB} incidence, good tolerance, and sustained adherence.},
  keywords = {adherence ; isoniazid preventive therapy ; {TB}-{HIV} ; {SWAZILAND}},
  booktitle = {},
  journal = {{M}edicine},
  volume = {96},
  numero = {35},
  pages = {e7740 [6 p.]},
  ISSN = {0025-7974},
  year = {2017},
  DOI = {10.1097/md.0000000000007740},
  URL = {https://www.documentation.ird.fr/hor/fdi:010071002},
}