@article{fdi:010070987,
  title = {{L}eishmania infections : molecular targets and diagnosis},
  author = {{A}khoundi, {M}. and {D}owning, {T}. and {V}otypka, {J}. and {K}uhls, {K}. and {L}ukes, {J}. and {C}annet, {A}. and {R}avel, {C}. and {M}arty, {P}. and {D}elaunay, {P}. and {K}asbari, {M}. and {G}ranouillac, {B}runo and {G}radoni, {L}. and {S}ereno, {D}enis},
  editor = {},
  language = {{ENG}},
  abstract = {{P}rogress in the diagnosis of leishmaniases depends on the development of effective methods and the discovery of suitable biomarkers. {W}e propose firstly an update classification of {L}eishmania species and their synonymies. {W}e demonstrate a global map highlighting the geography of known endemic {L}eishmania species pathogenic to humans. {W}e summarize a complete list of techniques currently in use and discuss their advantages and limitations. {T}he available data highlights the benefits of molecular markers in terms of their sensitivity and specificity to quantify variation from the subgeneric level to species complexes, (sub) species within complexes, and individual populations and infection foci. {E}ach {DNA}-based detection method is supplied with a comprehensive description of markers and primers and proposal for a classification based on the role of each target and primer in the detection, identification and quantification of leishmaniasis infection. {W}e outline a genome-wide map of genes informative for diagnosis that have been used for {L}eishmania genotyping. {F}urthermore, we propose a classification method based on the suitability of well-studied molecular markers for typing the 21 known {L}eishmania species pathogenic to humans. {T}his can be applied to newly discovered species and to hybrid strains originating from inter-species crosses. {D}eveloping more effective and sensitive diagnostic methods and biomarkers is vital for enhancing {L}eishmania infection control programs.},
  keywords = {{M}olecular markers ; {D}iagnostic methods ; {H}ybrid strains ; {S}ympatric species ; {G}enome-wide map},
  booktitle = {},
  journal = {{M}olecular {A}spects of {M}edicine},
  volume = {57},
  numero = {},
  pages = {1--29},
  ISSN = {0098-2997},
  year = {2017},
  DOI = {10.1016/j.mam.2016.11.012},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070987},
}