@article{fdi:010070962,
  title = {{M}alaria, malnutrition, and birthweight : a meta-analysis using individual participant data},
  author = {{C}ates, {J}. {E}. and {U}nger, {H}. {W}. and {B}riand, {V}al{\'e}rie and {F}ievet, {N}adine and {V}alea, {I}. and {T}into, {H}. and {D}'{A}lessandro, {U}. and {L}andis, {S}. {H}. and {A}du-{A}farwuah, {S}. and {D}ewey, {K}. {G}. and {T}er {K}uile, {F}. {O}. and {D}esai, {M}. and {D}ellicour, {S}. and {O}uma, {P}. and {G}utman, {J}. and {O}neko, {M}. and {S}lutsker, {L}. and {T}erlouw, {D}. {J}. and {K}ariuki, {S}. and {A}yisi, {J}. and {M}adanitsa, {M}. and {M}wapasa, {V}. and {A}shorn, {P}. and {M}aleta, {K}. and {M}ueller, {I}. and {S}tanisic, {D}. and {S}chmiegelow, {C}. and {L}usingu, {J}. {P}. {A}. and van {E}ijk, {A}. {M}. and {B}auserman, {M}. and {A}dair, {L}. and {C}ole, {S}. {R}. and {W}estreich, {D}. and {M}eshnick, {S}. and {R}ogerson, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {F}our studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight ({LBW}; <2,500 g) may depend upon maternal nutritional status. {W}e investigated this dependence further using a large, diverse study population. {M}ethods and findings {W}e evaluated the interaction between maternal malaria infection and maternal anthropometric status on the risk of {LBW} using pooled data from 14,633 pregnancies from 13 studies (6 cohort studies and 7 randomized controlled trials) conducted in {A}frica and the {W}estern {P}acific from 1996-2015. {S}tudies were identified by the {M}aternal {M}alaria and {M}alnutrition ({M}3) initiative using a convenience sampling approach and were eligible for pooling given adequate ethical approval and availability of essential variables. {S}tudy-specific adjusted effect estimates were calculated using inverse probability of treatment-weighted linear and log-binomial regression models and pooled using a random-effects model. {T}he adjusted risk of delivering a baby with {LBW} was 8.8% among women with malaria infection at antenatal enrollment compared to 7.7% among uninfected women (adjusted risk ratio [a{RR}] 1.14 [95% confidence interval ({CI}): 0.91, 1.42]; {N} = 13,613), 10.5% among women with malaria infection at delivery compared to 7.9% among uninfected women (a{RR} 1.32 [95% {CI}: 1.08, 1.62]; {N} = 11,826), and 15.3% among women with low mid-upper arm circumference ({MUAC} <23 cm) at enrollment compared to 9.5% among women with {MUAC} >= 23 cm (a{RR} 1.60 [95% {CI}: 1.36, 1.87]; {N} = 9,008). {T}he risk of delivering a baby with {LBW} was 17.8% among women with both malaria infection and low {MUAC} at enrollment compared to 8.4% among uninfected women with {MUAC} >= 23 cm (joint a{RR} 2.13 [95% {CI}: 1.21, 3.73]; {N} = 8,152). {T}here was no evidence of synergism (i.e., excess risk due to interaction) between malaria infection and {MUAC} on the multiplicative (p = 0.5) or additive scale (p = 0.9). {R}esults were similar using body mass index ({BMI}) as an anthropometric indicator of nutritional status. {M}eta-regression results indicated that there may be multiplicative interaction between malaria infection at enrollment and low {MUAC} within studies conducted in {A}frica; however, this finding was not consistent on the additive scale, when accounting for multiple comparisons, or when using other definitions of malaria and malnutrition. {T}he major limitations of the study included availability of only 2 cross-sectional measurements of malaria and the limited availability of ultrasound-based pregnancy dating to assess impacts on preterm birth and fetal growth in all studies. {C}onclusions {P}regnant women with malnutrition and malaria infection are at increased risk of {LBW} compared to women with only 1 risk factor or none, but malaria and malnutrition do not act synergistically.},
  keywords = {{AFRIQUE} ; {PACIFIQUE} ; {OUEST} ; {PAPOUASIE} {NOUVELLE}-{GUINEE} ; {MALAWI} ; {KENYA} ; {GHANA} ; {BURKINA} {FASO} ; {BENIN} ; {TANZANIE} ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{PLOS} {M}edicine},
  volume = {14},
  numero = {8},
  pages = {e1002373 [20 p.]},
  ISSN = {1549-1676},
  year = {2017},
  DOI = {10.1371/journal.pmed.1002373},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070962},
}