@article{fdi:010070947,
  title = {{L}ongitudinal study of changes in gamma delta {T} cells and {CD}4+ {T} cells upon asymptomatic malaria infection in {I}ndonesian children},
  author = {de {J}ong, {S}. {E}. and {A}sscher, {V}. {E}. {R}. and {W}ammes, {L}. {J}. and {W}iria, {A}. {E}. and {H}amid, {F}. and {S}artono, {E}. and {S}upali, {T}. and {S}mits, {H}. {H}. and {L}uty, {A}drian and {Y}azdanbakhsh, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}oth gamma delta {T} cells and {CD}4+ {T} cells have been implicated in immunity to malaria, but their association with natural gain or loss of infection has not been studied before. {T}herefore, we followed up asymptomatic children living in an area endemic for malaria in {I}ndonesia for 21 months. {T}he percentage of gamma delta {T} cells was related to both current and previous infection, with higher percentages in infected than uninfected children and declining after infections resolve. {I}nfected children also had higher levels of {T}h1 and {T}h17 cells, lower levels of {CD}25{H}i {FOXP}3+ regulatory {T} cells ({T}regs), but similar levels of {T}h2 cells as compared to uninfected children. {H}owever, {TNF}, {IFN}-gamma, and {IL}-17 cytokine responses to {P}lasmodium falciparuminfected red blood cells ({P}f{RBC}s) were similar, while {IL}-5 and {IL}-13 responses were lower in infected children. {F}urthermore, infected children had more phenotypically exhausted {PD}-1+ {CD}4+ {T} cells, more {T}regs expressing {TNF}-{RII}, and higher {IL}-10 responses to {P}f{RBC}s, which persisted following resolution of infection. {A}ltogether, this study demonstrates that asymptomatic malaria infection is associated with some long-lasting changes in the frequencies and immunoregulation of circulating innate and adaptive {T} cells, which might in part explain how pre-exposure to malaria affects responses to subsequent immunological challenges.},
  keywords = {{INDONESIE}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {7},
  numero = {},
  pages = {art. 8844 [7 p.]},
  ISSN = {2045-2322},
  year = {2017},
  DOI = {10.1038/s41598-017-09099-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070947},
}