Longitudinal study of changes in gamma delta T cells and CD4+ T cells upon asymptomatic malaria infection in Indonesian children

2017

Article référencé dans le Web of Science WOS:000407980000098

de Jong S. E., Asscher V. E. R., Wammes L. J., Wiria A. E., Hamid F., Sartono E., Supali T., Smits H. H., Luty Adrian, Yazdanbakhsh M.

Scientific Reports - Nature, 2017, 7, p. art. 8844 [7 p.] ISSN 2045-2322

Both gamma delta T cells and CD4+ T cells have been implicated in immunity to malaria, but their association with natural gain or loss of infection has not been studied before. Therefore, we followed up asymptomatic children living in an area endemic for malaria in Indonesia for 21 months. The percentage of gamma delta T cells was related to both current and previous infection, with higher percentages in infected than uninfected children and declining after infections resolve. Infected children also had higher levels of Th1 and Th17 cells, lower levels of CD25Hi FOXP3+ regulatory T cells (Tregs), but similar levels of Th2 cells as compared to uninfected children. However, TNF, IFN-gamma, and IL-17 cytokine responses to Plasmodium falciparuminfected red blood cells (PfRBCs) were similar, while IL-5 and IL-13 responses were lower in infected children. Furthermore, infected children had more phenotypically exhausted PD-1+ CD4+ T cells, more Tregs expressing TNF-RII, and higher IL-10 responses to PfRBCs, which persisted following resolution of infection. Altogether, this study demonstrates that asymptomatic malaria infection is associated with some long-lasting changes in the frequencies and immunoregulation of circulating innate and adaptive T cells, which might in part explain how pre-exposure to malaria affects responses to subsequent immunological challenges.

Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]

INDONESIE

Fonds IRD [F B010070947]

fdi:010070947