@article{fdi:010070937,
  title = {{I}nvestigation of correlates of protection against pharyngeal carriage of {N}eisseria meningitidis genogroups {W} and {Y} in the {A}frican meningitis belt},
  author = {{C}ooper, {L}. {V}. and {B}oukary, {R}. {M}. and {A}seffa, {A}. and {M}ihret, {W}. and {C}ollard, {J}. {M}. and {D}augla, {D}. and {H}odgson, {A}. and {S}okhna, {C}heikh and {O}motara, {B}. and {S}ow, {S}. and {Q}uaye, {S}. {L}. and {D}iallo, {K}. and {M}anigart, {O}. and {M}aiden, {M}. {C}. {J}. and {F}indlow, {H}. and {B}orrow, {R}. and {S}tuart, {J}. {M}. and {G}reenwood, {B}. {M}. and {T}rotter, {C}. {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {S}erum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. {H}owever, titres that are associated with protection against acquisition of pharyngeal carriage of {N}eisseria meningitidis are not known. {M}ethods {S}era were obtained from the members of a household in seven countries of the {A}frican meningitis belt in which a pharyngeal carrier of {N}. meningitidis had been identified during a cross-sectional survey. {S}erum bactericidal antibody titres at baseline were compared between individuals in the household of the carrier who became a carrier of a meningococcus of the same genogroup during six months of subsequent follow-up and household members who did not become a carrier of a meningococcus of this genogroup during this period. {R}esults {S}erum bacterial antibody titres were significantly higher in carriers of a serogroup {W} or {Y} meningococcus at the time of recruitment than in those who were not a carrier of {N}. meningitidis of the same genogroup. {S}erum bactericidal antibody titres to a strain of {N}. meningitis of the same genogroup as the index cases were no different in individuals who acquired carriage with a meningococcus of the same genogroup as the index case than in those who did not become a carrier during six months of follow-up. {C}onclusion {S}erum bacterial antibody titres to {N}. meningitidis of genogroup {W} or {Y} in the range of those acquired by natural exposure to meningococci of these genogroups, or with cross-reactive bacteria, are not associated with protection against acquisition of carriage with meningococci of either of these genogroups.},
  keywords = {{TCHAD}, {ETHIOPIE}, {GHANA}, {MALI}, {NIGER}, {NIGERIA} ; {SENEGAL}},
  booktitle = {},
  journal = {{PLOS} {O}ne},
  volume = {12},
  numero = {8},
  pages = {e0182575 [13 p.]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0182575},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070937},
}