@article{fdi:010070936,
  title = {{C}ontemporary status of insecticide resistance in the major {A}edes vectors of arboviruses infecting humans},
  author = {{M}oyes, {C}. {L}. and {V}ontas, {J}. and {M}artins, {A}. {J}. and {N}g, {L}. {C}. and {K}oou, {S}. {Y}. and {D}usfour, {I}. and {R}aghavendra, {K}. and {P}into, {J}. and {C}orbel, {V}incent and {D}avid, {J}. {P}. and {W}eetman, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}oth {A}edes aegytpi and {A}e. albopictus are major vectors of 5 important arboviruses (namely chikungunya virus, dengue virus, {R}ift {V}alley fever virus, yellow fever virus, and {Z}ika virus), making these mosquitoes an important factor in the worldwide burden of infectious disease. {V}ector control using insecticides coupled with larval source reduction is critical to control the transmission of these viruses to humans but is threatened by the emergence of insecticide resistance. {H}ere, we review the available evidence for the geographical distribution of insecticide resistance in these 2 major vectors worldwide and map the data collated for the 4 main classes of neurotoxic insecticide (carbamates, organochlorines, organophosphates, and pyrethroids). {E}merging resistance to all 4 of these insecticide classes has been detected in the {A}mericas, {A}frica, and {A}sia. {T}arget-site mutations and increased insecticide detoxification have both been linked to resistance in {A}e. aegypti and {A}e. albopictus but more work is required to further elucidate metabolic mechanisms and develop robust diagnostic assays. {G}eographical distributions are provided for the mechanisms that have been shown to be important to date. {E}stimating insecticide resistance in unsampled locations is hampered by a lack of standardisation in the diagnostic tools used and by a lack of data in a number of regions for both resistance phenotypes and genotypes. {T}he need for increased sampling using standard methods is critical to tackle the issue of emerging insecticide resistance threatening human health. {S}pecifically, diagnostic doses and well-characterised susceptible strains are needed for the full range of insecticides used to control {A}e. aegypti and {A}e. albopictus to standardise measurement of the resistant phenotype, and calibrated diagnostic assays are needed for the major mechanisms of resistance.},
  keywords = {{AMERIQUE} ; {AFRIQUE} ; {ASIE}},
  booktitle = {},
  journal = {{PLOS} {N}eglected {T}ropical {D}iseases},
  volume = {11},
  numero = {7},
  pages = {e0005625 [20 p.]},
  ISSN = {1935-2735},
  year = {2017},
  DOI = {10.1371/journal.pntd.0005625},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070936},
}