@article{fdi:010070905,
  title = {{P}rospective cohort study of the feasibility and yield of household child tuberculosis contact screening in {U}ganda},
  author = {{B}onnet, {M}aryline and {K}yakwera, {C}. and {K}yomugasho, {N}. and {A}twine, {D}. and {M}ugabe, {F}. and {N}ansumba, {M}. and {B}oum, {Y}. and {M}wanga-{A}mumpaire, {J}. and {K}iwanuka, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{SETTING}: {S}creening and isoniazid preventive therapy ({IPT}) of child contacts of tuberculosis ({TB}) patients is 'poorly implemented in resource-limited countries, in part due to difficulties in {TB} diagnosis in children. {OBJECTIVE}: {T}o assess the feasibility and yield of hospital-based screening and {IPT} in {U}ganda, and to evaluate the utility of symptom-based screening. {DESIGN}: {H}ousehold child (age <5 years) contacts of adults with pulmonary {TB} were assessed for {TB} or latent tuberculous infection ({LTBI}). {C}hildren classified as '{LTBI}' or 'uninfected' were prescribed {IPT} and followed for 9 months. {S}creening algorithms based on combinations of symptoms associated with {TB} were constructed post hoc, and their performance evaluated against a radiological-based reference standard. {RESULTS}: {O}f 281 contacts (median age 33 months), 44 (15.7%) started anti-tuberculosis treatment and 234 (83.3%) received {IPT}, 80.3% of whom completed a 6 month course. {A}fter adjustment for age and human immunodeficiency virus status, cough (a{OR} 4.10, 95%{CI} 1.39-12.11) and reduced playfulness (a{OR} 7.79, 95%{CI} 2.12-25.18) were associated with radiological {TB}. {S}creening based on cough or reduced playfulness had a sensitivity of 81.8% and a negative predictive value of 97.6%. {CONCLUSION}: {H}ospital-based screening appears to be feasible, and confirms the potential utility of symptom based screening to select children for {IPT} and those for further investigations.},
  keywords = {childhood tuberculosis ; symptom-based screening ; {OUGANDA}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {T}uberculosis and {L}ung {D}isease},
  volume = {21},
  numero = {8},
  pages = {862--868},
  ISSN = {1027-3719},
  year = {2017},
  DOI = {10.5588/ijtld.16.0889},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070905},
}