@article{fdi:010070380,
  title = {{T}emporal analysis of {I}g{G} antibody responses to {P}lasmodium falciparum antigens in relation to changing malaria epidemiology in a {W}est {A}frican setting},
  author = {{N}iang, {M}. and {N}iass, {O}. and {D}iagne, {N}. and {S}arr, {F}. {D}. and {F}aye, {M}. {M}. and {D}iop, {F}. and {D}iouf, {B}. and {F}aye, {J}. and {B}adiane, {A}. and {P}erraut, {R}. and {S}okhna, {C}heikh and {T}rape, {J}ean-{F}ran{\c{c}}ois and {T}all, {A}. and {T}oure-{B}alde, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {C}oordinated scaled-up malaria control interventions have substantially contributed to the dramatic decrease of malaria-related morbidity and mortality in several endemic countries, including {S}enegal. {H}owever, the impacts of a given malaria control intervention on vector and parasite populations, acquired immunity, and disease burden remain very poorly documented largely due to the lack of continuous surveys. {T}his study took advantage of the sera bank established as part of the {D}ielmo longitudinal project to investigate the dynamics of {I}g{G} antibody responses that accompanied the epidemiological changes resulting from malaria control interventions. {S}chizonts crude extract of a local strain of {P}lasmodium falciparum ({P}fsch07/03) was used in {ELISA} to measure and compare seroprevalence and magnitude of {I}g{G} antibody responses from 2000 to 2012. {R}esults: {T}he prevalence of {P}fsch07/03 {I}g{G} antibody responses progressively decreased from 97.25% in 2000 to 57.3% in 2012. {T}he prevalence of {P}fsch07/03 antibodies categorized between three different age groups (<7, 7-15, and > 15 years) revealed increased seroprevalence with age ranging from 47.19 to 62.67 and 89.45%, respectively in (<7, 7-15, and > 15 years) old age groups. {A} marked drop in seroprevalence was observed after 2008 and was significant in the younger (< 7 years) and intermediate (7-15 years) age groups, unlike older individuals aged > 15 years (p = 1.00). {C}onclusions: {T}he study revealed a substantial contribution of all malaria control interventions to the decrease of {I}g{G} antibodies responses to {P}fsch07/03 throughout prevention of human-mosquitos contacts, or reduction of parasite biomass. {T}he present study demonstrates the wider potential of sero-epidemiological analysis in monitoring changes in malaria transmission resulting from a given malaria control intervention.},
  keywords = {{M}alaria ; {T}ransmission ; {I}mmunity ; {C}ontrols ; {SENEGAL}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {16},
  numero = {},
  pages = {art. 283 [8 p.]},
  ISSN = {1475-2875},
  year = {2017},
  DOI = {10.1186/s12936-017-1928-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070380},
}