@article{fdi:010070379,
  title = {{T}he peptidoglycan recognition proteins {PGRPLA} and {PGRPLB} regulate {A}nopheles immunity to bacteria and affect infection by {P}lasmodium},
  author = {{G}endrin, {M}. and {T}urlure, {F}. and {R}odgers, {F}. {H}. and {C}ohuet, {A}nna and {M}orlais, {I}sabelle and {C}hristophides, {G}. {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}eptidoglycan recognition proteins ({PGRP}s) form a family of immune regulators that is conserved from insects to mammals. {I}n the malaria vector mosquito {A}nopheles coluzzii, the peptidoglycan receptor {PGRPLC} activates the immune-deficiency ({I}md) pathway limiting both the microbiota load and {P}lasmodium infection. {H}ere, we carried out an {RNA} interference screen to examine the role of all 7 {A}nopheles {PGRP}s in infections with {P}lasmodium berghei and {P}. falciparum. {W}e show that, in addition to {PGRPLC}, {PGRPLA} and {PGRPS}2/{PGRPS}3 also participate in antiparasitic defenses, and that {PGRPLB} promotes mosquito permissiveness to {P}. falciparum. {W}e also demonstrate that following a mosquito blood feeding, which promotes growth of the gut microbiota, {PGRPLA} and {PGRPLB} positively and negatively regulate the activation of the {I}md pathway, respectively. {O}ur data demonstrate that {PGRP}s are important regulators of the mosquito epithelial immunity and vector competence.},
  keywords = {{P}eptidoglycan recognition protein ; {A}nopheles ; {D}rosophila ; {I}mmune-deficiency pathway ; {A}ntimicrobial peptides ; {P}lasmodium ; {M}icrobiota ; {B}acteria ; {CAMEROUN}},
  booktitle = {},
  journal = {{J}ournal of {I}nnate {I}mmunity},
  volume = {9},
  numero = {4},
  pages = {333--342},
  ISSN = {1662-811{X}},
  year = {2017},
  DOI = {10.1159/000452797},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070379},
}