Publications des scientifiques de l'IRD

Heffelfinger C., Fragoso C. A., Lorieux Mathias. (2017). Constructing linkage maps in the genomics era with MapDisto 2.0. Bioinformatics, 33 (14), p. 2224-2225. ISSN 1367-4803.

Titre du document
Constructing linkage maps in the genomics era with MapDisto 2.0
Année de publication
2017
Type de document
Article référencé dans le Web of Science WOS:000405289100076
Auteurs
Heffelfinger C., Fragoso C. A., Lorieux Mathias
Source
Bioinformatics, 2017, 33 (14), p. 2224-2225 ISSN 1367-4803
Motivation: Genotyping by sequencing (GBS) generates datasets that are challenging to handle by current genetic mapping software with graphical interface. Geneticists need new user-friendly computer programs that can analyze GBS data on desktop computers. This requires improvements in computation efficiency, both in terms of speed and use of random-access memory (RAM). Results: MapDisto v. 2.0 is a user-friendly computer program for construction of genetic linkage maps. It includes several new major features: (i) handling of very large genotyping datasets like the ones generated by GBS; (ii) direct importation and conversion of Variant Call Format (VCF) files; (iii) detection of linkage, i.e. construction of linkage groups in case of segregation distortion; (iv) data imputation on VCF files using a new approach, called LB-Impute. Features i to iv operate through inclusion of new Java modules that are used transparently by MapDisto; (v) QTL detection via a new R./qtl graphical interface.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
Localisation
Fonds IRD [F B010070310]
Identifiant IRD
fdi:010070310
Contact