@article{fdi:010070273,
  title = {{P}arasites causing cerebral {F}alciparum malaria bind multiple endothelial receptors and express {EPCR} and {ICAM}-1-binding {P}f{EMP}1},
  author = {{T}uikue {N}dam, {N}icaise and {M}oussiliou, {A}. and {L}avstsen, {T}. and {K}amaliddin, {C}. and {J}ensen, {A}. {T}. {R}. and {M}ama, {A}. and {T}ahar, {R}achida and {W}ang, {C}. {W}. and {J}espersen, {J}. {S}. and {A}lao, {J}. {M}. and {G}amain, {B}. and {T}heander, {T}. {G}. and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {P}lasmodium falciparum erythrocyte membrane protein 1 ({P}f{EMP}1) mediates the binding and accumulation of infected erythrocytes ({IE}) to blood vessels and tissues. {S}pecific interactions have been described between {P}f{EMP}1 and human endothelial proteins {CD}36, intercellular adhesion molecule-1 ({ICAM}-1), and endothelial protein {C} receptor ({EPCR}); however, cytoadhesion patterns typical for pediatric malaria syndromes and the associated {P}f{EMP}1 members are still undefined. {M}ethods. {I}n a cohort of 94 hospitalized children with malaria, we characterized the binding properties of {IE} collected on admission, and var gene transcription using quantitative polymerase chain reaction. {R}esults. {IE} from patients with cerebral malaria were more likely to bind {EPCR} and {ICAM}-1 than {IE} from children with uncomplicated malaria ({P} = .007). {T}he level of transcripts encoding {CIDR} alpha 1.4 and {CIDR} alpha 1.5 domain subclasses was higher in patients with severe disease ({P} <.05). {IE} populations exhibiting binding to all 3 receptors had higher levels of transcripts encoding {P}f{EMP}1 with {CIDR}a1.4 and {D}uffy binding-like ({DBL})-beta 3 domains than parasites, which only bound {CD}36. {C}onclusions. {T}hese results underpin the significance of {EPCR} binding in pediatric malaria patients that require hospital admission, and support the notion that complementary receptor interactions of {EPCR} binding {P}f{EMP}1 with {ICAM}-1 amplifies development of severe malaria symptoms.},
  keywords = {cerebral malaria ; {EPCR} ; {ICAM}-1 ; {P}f{EMP}1 ; {P}lasmodium falciparum ; {BENIN} ; {COTONOU}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {215},
  numero = {12},
  pages = {1918--1925},
  ISSN = {0022-1899},
  year = {2017},
  DOI = {10.1093/infdis/jix230},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070273},
}