@article{fdi:010070261,
  title = {{M}odifications of the soluble proteome of a {M}editerranean strain of the invasive neurotoxic dinoflagellate {A}lexandrium catenella under metal stress conditions},
  author = {{J}ean, {N}. and {D}umont, {E}. and {H}erzi, {F}. and {B}alliau, {T}. and {L}aabir, {M}ohamed and {M}asseret, {E}stelle and {M}ounier, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he soluble proteome of the mediterranean strain {ACT}03 of the invasive neurotoxic dinoflagellate {A}lexandrium catenella exposed to lead or zinc at 6, 12 or 18 mu {M} (total concentrations), or under control conditions, was characterized by two-dimensional gel electrophoresis (2-{DE}). {Z}inc reduced ({P} < 0.05) the total number of protein spots (-41%, -52% and -60%, at 6, 12 or 18 {M}, respectively). {B}esides, most of the proteins constituting the soluble proteome were down-regulated in response to lead or zinc stresses. {T}hese proteins were involved mainly in photosynthesis (20-37% for lead; 36-50% for zinc) (ribulose-1,5-bisphosphate carboxylase/oxygenase: {RUBISCO}; ferredoxin-{NADP}(+) reductase: {FNR}; peridinin-chlorophyll a-protein: {PCP}), and in the oxidative stress response (29-34% for lead; 17-36% for zinc) (superoxide dismutase: {SOD}; proteasome alpha/beta subunits). {T}hese negative effects could be partly compensated by the up-regulation of specific proteins such as {ATP}-synthase beta subunit (+16.3 fold after exposure to lead at 12 {M}). {I}ndeed, an increase in the abundance of {ATP}-synthase could enrich the {ATP} pool and provide more energy available for the cells to survive under metal stress, and make the {ATP}-synthase transport of metal cations out of the cells more efficient. {F}inally, this study shows that exposure to lead or zinc have a harmful effect on the soluble proteome of {A}. catenella {ACT}03, but also suggests the existence of an adaptative proteomic response to metal stresses, which could contribute to maintaining the development of this dinoflagellate in trace metal-contaminated ecosystems.},
  keywords = {{A}lexandrium catenella ; {H}armful algal bloom ; {P}roteomics ; {S}tress proteins ; {T}race metals},
  booktitle = {},
  journal = {{A}quatic {T}oxicology},
  volume = {188},
  numero = {},
  pages = {80--91},
  ISSN = {0166-445{X}},
  year = {2017},
  DOI = {10.1016/j.aquatox.2017.04.011},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070261},
}