@article{fdi:010070240,
  title = {{E}ffect of 3 years of biannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections : a community-based study in {R}epublic of the {C}ongo},
  author = {{P}ion, {S}{\'e}bastien and {C}hesnais, {C}. {B}. and {W}eil, {G}. {J}. and {F}ischer, {P}. {U}. and {M}issamou, {F}. and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {T}he standard treatment strategy of mass drug administration with ivermectin plus albendazole for lymphatic filariasis cannot be applied in central {A}frica, because of the risk of serious adverse events in people with high {L}oa loa microfilaraemia. {T}hus, alternative strategies are needed. {W}e investigated one such alternative strategy for mass drug administration for elimination of lymphatic filariasis and soil-transmitted helminth infections in {R}epublic of the {C}ongo. {M}ethods {I}n 2012, we started a 3 year community trial of biannual mass administration of albendazole in a village in {R}epublic of the {C}ongo. {A}ll volunteering inhabitants aged 2 years or older were offered albendazole (400 mg) every 6 months. {I}nfection with {W}uchereria bancrofti was diagnosed with a rapid card immunochromatographic test for antigenaemia. {P}eople with antigenaemia were tested for microfilaraemia by night blood smears. {I}ndividuals were also tested for soil-transmitted helminth infections (ie, hookworm, {A}scaris lumbricoides, {T}richuris trichiura) with the {K}ato-{K}atz method. {A}ssessment surveys were done at 12, 24, and 36 months. {T}he main outcome measure was change in infection rates from baseline to year 3. {F}indings {T}herapeutic coverage was more than 80% in all six rounds of mass administration of albendazole. {B}etween 2012 and 2015, {W} bancrofti antigenaemia and microfilaraemia rates in the community fell significantly, from 17.3% (95% {CI} 14.7-20.0) to 4.7% (3.3-6.6; p<0.0001) and from 5.3% (3.9-7.1) to 0.3% (0.1-1.2; p<0.0001), respectively. {T}he geometric mean microfilaria count in microfilaraemic people fell from 199.4 (120.4-330.5) per m{L} in 2012 to 39.1 (95% {CI}s not computed) per m{L} in 2015 (p=0.0095). {H}ookworm infection was undetectable after 1 year. {B}etween 2012 and 2015, the number of {A} lumbricoides eggs expelled per g of faeces fell from 9844.6 (82090-11 480.0) to 7244 (3407-11142; p<00001), and of {T} trichiura eggs from 11074 (878.5-1336.3) to 366.0 (255.7-4762; p<0.0001). {I}nterpretation {O}ur findings strongly support {WHO}'s provisional strategy of biannual mass administration of albendazole to eliminate lymphatic filariasis in areas where loiasis is co-endemic and ivermectin cannot be safely mass administered.},
  keywords = {{CONGO}},
  booktitle = {},
  journal = {{L}ancet {I}nfectious {D}iseases},
  volume = {17},
  numero = {7},
  pages = {763--769},
  ISSN = {1473-3099},
  year = {2017},
  DOI = {10.1016/s1473-3099(17)30175-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070240},
}