Horizon / Plein textes La base de ressources documentaires de l'IRD

IRD

Publications des scientifiques de l'IRD

Pion Sébastien, Chesnais C. B., Weil G. J., Fischer P. U., Missamou F., Boussinesq Michel. (2017). Effect of 3 years of biannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections : a community-based study in Republic of the Congo. Lancet Infectious Diseases, 17 (7), 763-769. ISSN 1473-3099

Accès réservé (Intranet IRD) Document en accès réservé (Intranet IRD)

Lien direct chez l'éditeur doi:10.1016/s1473-3099(17)30175-5

Titre
Effect of 3 years of biannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections : a community-based study in Republic of the Congo
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000403825500042
AuteursPion Sébastien, Chesnais C. B., Weil G. J., Fischer P. U., Missamou F., Boussinesq Michel.
SourceLancet Infectious Diseases, 2017, 17 (7), p. 763-769. ISSN 1473-3099
RésuméBackground The standard treatment strategy of mass drug administration with ivermectin plus albendazole for lymphatic filariasis cannot be applied in central Africa, because of the risk of serious adverse events in people with high Loa loa microfilaraemia. Thus, alternative strategies are needed. We investigated one such alternative strategy for mass drug administration for elimination of lymphatic filariasis and soil-transmitted helminth infections in Republic of the Congo. Methods In 2012, we started a 3 year community trial of biannual mass administration of albendazole in a village in Republic of the Congo. All volunteering inhabitants aged 2 years or older were offered albendazole (400 mg) every 6 months. Infection with Wuchereria bancrofti was diagnosed with a rapid card immunochromatographic test for antigenaemia. People with antigenaemia were tested for microfilaraemia by night blood smears. Individuals were also tested for soil-transmitted helminth infections (ie, hookworm, Ascaris lumbricoides, Trichuris trichiura) with the Kato-Katz method. Assessment surveys were done at 12, 24, and 36 months. The main outcome measure was change in infection rates from baseline to year 3. Findings Therapeutic coverage was more than 80% in all six rounds of mass administration of albendazole. Between 2012 and 2015, W bancrofti antigenaemia and microfilaraemia rates in the community fell significantly, from 17.3% (95% CI 14.7-20.0) to 4.7% (3.3-6.6; p<0.0001) and from 5.3% (3.9-7.1) to 0.3% (0.1-1.2; p<0.0001), respectively. The geometric mean microfilaria count in microfilaraemic people fell from 199.4 (120.4-330.5) per mL in 2012 to 39.1 (95% CIs not computed) per mL in 2015 (p=0.0095). Hookworm infection was undetectable after 1 year. Between 2012 and 2015, the number of A lumbricoides eggs expelled per g of faeces fell from 9844.6 (82090-11 480.0) to 7244 (3407-11142; p<00001), and of T trichiura eggs from 11074 (878.5-1336.3) to 366.0 (255.7-4762; p<0.0001). Interpretation Our findings strongly support WHO's provisional strategy of biannual mass administration of albendazole to eliminate lymphatic filariasis in areas where loiasis is co-endemic and ivermectin cannot be safely mass administered.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052]
Descr. géo.CONGO
LocalisationFonds IRD [F B010070240]
Identifiant IRDfdi:010070240
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010070240

Export des données

Disponibilité des documents

Télechargment fichier PDF téléchargeable

Lien sur le Web lien chez l'éditeur

Accès réservé en accès réservé

HAL en libre accès sur HAL


Accès aux documents originaux :

Le FDI est labellisé CollEx

Accès direct

Bureau du chercheur

Site de la documentation

Espace intranet IST (accès réservé)

Suivi des publications IRD (accès réservé)

Mentions légales

Services Horizon

Poser une question

Consulter l'aide en ligne

Déposer une publication (accès réservé)

S'abonner au flux RSS

Voir les tableaux chronologiques et thématiques

Centres de documentation

Bondy

Montpellier (centre IRD)

Montpellier (MSE)

Nouméa

Papeete

Niamey

Ouagadougou

Tunis

La Paz

Quito