@article{fdi:010070221,
  title = {{S}erological signatures of declining exposure following intensification of integrated malaria control in two rural {S}enegalese communities},
  author = {{P}erraut, {R}. and {V}arela, {M}. {L}. and {L}oucoubar, {C}. and {N}iass, {O}. and {S}idibe, {A}. and {T}all, {A}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {W}otodjo, {A}. {N}. and {M}bengue, {B}. and {S}okhna, {C}heikh and {V}igan-{W}omas, {I}. and {T}oure, {A}. and {R}ichard, {V}. and {M}ercereau-{P}uijalon, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{R}ecent control scale-up has reduced malaria in many areas but new tools are needed to monitor further progress, including indicators of decreasing exposure to parasite infection. {A}lthough serology is considered a promising approach in this regard, the serological impact of control interventions has been so far studied using indirect quantification of exposure. {C}ohort surveys concomitantly recording entomological and malariometric indices have been conducted in two {S}enegalese settings where supervised control intensification implemented in 2006 shifted malaria from historically holoendemic in {D}ielmo and mesoendemic in {N}diop to hypoendemic in both settings by 2013. {W}e analyse here serological signatures of declining transmission using archived blood samples. {R}esponses against ten pre-erythrocytic and erythrocytic antigens from {P}lasmodium falciparum and {P}. malariae alongside an {A}nopheles gambiae salivary gland antigen were analysed. {C}ross-sectional surveys conducted before (2002) and after (2013) control intensification showed a major impact of control intensification in both settings. {T}he age-associated prevalence, magnitude and breadth of the {I}g{G} responses to all antigens were village-specific in 2002. {I}n 2013, remarkably similar patterns were observed in both villages, with marginal responses against all parasite antigens in the 0-5y children and reduced responses in all previously seropositive age groups. {W}aning of humoral responses of individuals who were immune at the time of control intensification was studied from 2006 to 2013 using yearly samplings. {L}ongitudinal data were analysed using the {C}ochran-{A}rmittage trend test and an age-related reversible catalytic conversion model. {T}his showed that the antigen-specific antibody declines were more rapid in older children than adults. {T}here was a strong association of antibody decline with the declining entomological inoculation rate. {W}e thus identified serological markers of declining exposure to malaria parasites that should help future monitoring of progress towards malaria elimination.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {12},
  numero = {6},
  pages = {e0179146 [19 p.]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0179146},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070221},
}