@article{fdi:010070138,
  title = {{P}henolic compounds isolated from {C}aesalpinia coriaria induce {S} and {G}2/{M} phase cell cycle arrest differentially and trigger cell death by interfering with microtubule dynamics in cancer cell lines},
  author = {{S}anchez-{C}arranza, {J}.{N}. and {A}lvarez, {L}. and {M}arquina-{B}ahena, {S}. and {S}alas-{V}idal, {E}. and {C}uevas, {V}. and {J}imenez, {E}.{W}. and {V}eloz {G}., {R}.{A}. and {C}arraz, {M}a{\¨e}lle and {G}onzalez-{M}aya, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}aesalpinia coriaria ({C}. coriaria), also named cascalote, has been known traditionally in {M}{\'e}xico for having cicatrizing and inflammatory properties. {P}hytochemical reports on {C}aesalpinia species have identified a high content of phenolic compounds and shown antineoplastic effects against cancer cells. {T}he aim of this study was to isolate and identify the active compounds of a water:acetone:ethanol ({WAE}) extract of {C}. coriaria pods and characterize their cytotoxic effect and cell death induction in different cancer cell lines. {T}he compounds isolated and identified by chromatography and spectroscopic analysis were stigmasterol, ethyl gallate and gallic acid. {C}ytotoxic assays on cancer cells showed different ranges of activities. {A} differential effect on cell cycle progression was observed by flow cytometry. {I}n particular, ethyl gallate and tannic acid induced {G}2/{M} phase cell cycle arrest and showed interesting effect on microtubule stabilization in {H}ep3{B} cells observed by immunofluorescence. {T}he induction of apoptosis was characterized by morphological characteristic changes, and was supported by increases in the ratio of {B}ax/{B}cl-2 expression and activation of caspase 3/7. {T}his work constitutes the first phytochemical and cytotoxic study of {C}. coriaria and showed the action of its phenolic constituents on cell cycle, cell death and microtubules organization.},
  keywords = {{MEXIQUE}},
  booktitle = {},
  journal = {{M}olecules},
  volume = {22},
  numero = {4},
  pages = {art. no {E}666 [14  en ligne]},
  ISSN = {1420-3049},
  year = {2017},
  DOI = {10.3390/molecules22040666},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070138},
}