@article{fdi:010070036,
  title = {{H}eterozygous {H}b{AC} but not {H}b{AS} is associated with higher newborn birthweight among women with pregnancy-associated malaria},
  author = {{T}{\'e}tard, {M}. and {M}ilet, {J}acqueline and {D}echavanne, {S}. and {F}ievet, {N}adine and {D}orin-{S}emblat, {D}. and {E}lion, {J}. and {F}airhurst, {R}. {M}. and {D}eloron, {P}hilippe and {T}uikue {N}dam, {N}icaise and {G}amain, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}regnancy-associated malaria ({PAM}) is associated with poor pregnancy outcomes. {H}emoglobin {S} ({H}b{S}) and hemoglobin {C} ({H}b{C}) mutations are frequently encountered in malaria-endemic areas of {A}frica, where they protect children from severe and uncomplicated {P}lasmodium falciparum malaria. {H}owever, scant epidemiological data exist on the impact of these {H}b variants on {PAM}. {A} prospective cohort of 635 {B}eninese pregnant women was recruited before 24 weeks of gestational age and followed until the end of pregnancy. {H}b{AA}, {H}b{AC}, and {H}b{AS} genotypes were determined and tested for association with pregnancy outcomes and {PAM} indicators using linear and logistic multivariate models. {N}ewborns from {H}b{AC} mothers had higher birthweights than those from {H}b{AA} mothers among women infected at any time during pregnancy (mean difference 182.9g, p = 0.08), or during the first half of pregnancy (654.3g, p = 0.0006). {N}o such birthweight differences were observed between newborns from {H}b{AS} and {H}b{AA} mothers. {H}b{AC} and {H}b{AS} were not associated with other pregnancy outcomes or {PAM} indicators. {I}n conclusion, {H}b{AC} but not {H}b{AS} is associated with an improved birth outcome in pregnant women with documented {PAM}. {H}igher-birthweight newborns from {H}b{AC} mothers may have a survival advantage that contributes to the natural selection of {H}b{C} in malaria-endemic areas.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {7},
  numero = {},
  pages = {art. 1414 [8 p.]},
  ISSN = {2045-2322},
  year = {2017},
  DOI = {10.1038/s41598-017-01495-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070036},
}