Horizon / Plein textes La base de ressources documentaires de l'IRD

IRD

Publications des scientifiques de l'IRD

Tétard M., Milet Jacqueline, Dechavanne S., Fievet Nadine, Dorin-Semblat D., Elion J., Fairhurst R. M., Deloron Philippe, Tuikue Ndam Nicaise, Gamain B. (2017). Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria. Scientific Reports - Nature, 7, art. 1414 [8 p.]. ISSN 2045-2322

Fichier PDF disponible http://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-05/010070036.pdf

Lien direct chez l'éditeur doi:10.1038/s41598-017-01495-9

Titre
Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000400491100015
AuteursTétard M., Milet Jacqueline, Dechavanne S., Fievet Nadine, Dorin-Semblat D., Elion J., Fairhurst R. M., Deloron Philippe, Tuikue Ndam Nicaise, Gamain B.
SourceScientific Reports - Nature, 2017, 7, p. art. 1414 [8 p.]. p. art. 1414 [8 p.] ISSN 2045-2322
RésuméPregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data exist on the impact of these Hb variants on PAM. A prospective cohort of 635 Beninese pregnant women was recruited before 24 weeks of gestational age and followed until the end of pregnancy. HbAA, HbAC, and HbAS genotypes were determined and tested for association with pregnancy outcomes and PAM indicators using linear and logistic multivariate models. Newborns from HbAC mothers had higher birthweights than those from HbAA mothers among women infected at any time during pregnancy (mean difference 182.9g, p = 0.08), or during the first half of pregnancy (654.3g, p = 0.0006). No such birthweight differences were observed between newborns from HbAS and HbAA mothers. HbAC and HbAS were not associated with other pregnancy outcomes or PAM indicators. In conclusion, HbAC but not HbAS is associated with an improved birth outcome in pregnant women with documented PAM. Higher-birthweight newborns from HbAC mothers may have a survival advantage that contributes to the natural selection of HbC in malaria-endemic areas.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050]
Descr. géo.BENIN
LocalisationFonds IRD [F B010070036]
Identifiant IRDfdi:010070036
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010070036

Export des données

Disponibilité des documents

Télechargment fichier PDF téléchargeable

Lien sur le Web lien chez l'éditeur

Accès réservé en accès réservé

HAL en libre accès sur HAL


Accès aux documents originaux :

Accès direct

Bureau du chercheur

Site de la documentation

Espace intranet IST (accès réservé)

Suivi des publications IRD (accès réservé)

Mentions légales

Services Horizon

Poser une question

Consulter l'aide en ligne

Déposer une publication (accès réservé)

S'abonner au flux RSS

Voir les tableaux chronologiques et thématiques

Centres de documentation

Bondy

Montpellier (centre IRD)

Montpellier (MSE)

Nouméa

Papeete

Niamey

Ouagadougou

Tunis

La Paz

Quito