@article{fdi:010070004,
  title = {{M}easurement of circulating filarial antigen levels in human blood with a point-of-care test strip and a portable spectrodensitometer},
  author = {{C}hesnais, {C}. {B}. and {V}laminck, {J}. and {K}unyu-{S}hako, {B}. and {P}ion, {S}{\'e}bastien and {A}waca-{U}von, {N}. {P}. and {W}eil, {G}. {J}. and {M}umba, {D}. and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {A}lere {F}ilariasis {T}est {S}trip ({FTS}) is a qualitative, point-of-care diagnostic tool that detects {W}uchereria bancrofti circulating filarial antigen ({CFA}) in human blood, serum, or plasma. {T}he {G}lobal {P}rogram to {E}liminate {L}ymphatic {F}ilariasis employs the {FTS} for mapping filariasis-endemic areas and assessing the success of elimination efforts. {T}he objective of this study was to explore the relationship between the intensity of positive test lines obtained by {FTS} with {CFA} levels as determined by enzyme-linked immunosorbent assay ({ELISA}) with blood and plasma samples from 188 individuals who live in a filariasis-endemic area. {T}he intensity of the {FTS} test line was assessed visually to provide a semiquantitative score (visual {F}ilariasis {T}est {S}trip [v{FTS}]), and line intensity was measured with a portable spectrodensitometer (quantitative {F}ilariasis {T}est {S}trip [g{FTS}]). {T}hese results were compared with antigen levels measured by {ELISA} in plasma from the same subjects. q{FTS} measurements were highly correlated with v{FTS} scores (p = 0.94; {P} < 0.001) and with plasma {CFA} levels (p = 0.91; {P} < 0.001). {T}hus, q{FTS} assessment is a convenient method for quantifying {W} bancrofti {CFA} levels in human blood, which are correlated with adult worm burdens. {T}his tool may be useful for assessing the impact of treatment on adult filarial worms in individuals and communities.},
  keywords = {{REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {94},
  numero = {6},
  pages = {1324--1329},
  year = {2016},
  DOI = {10.4269/ajtmh.15-0916},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070004},
}