@article{fdi:010069991,
  title = {{I}nsecticide resistance status of malaria vectors in {L}ao {PDR}},
  author = {{M}arcombe, {S}. and {B}obichon, {J}. and {S}omphong, {B}. and {P}hommavan, {N}. and {M}aithaviphet, {S}. and {N}ambanya, {S}. and {C}orbel, {V}incent and {B}rey, {P}. {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{K}nowledge on insecticide resistance in {A}nopheles species is a basic requirement to guide malaria vector control programs. {I}n {L}ao {PDR}, vector control relies on insecticide residual spraying ({IRS}) and impregnated bed-nets ({ITN}s) with the use of pyrethroids. {H}ere, the susceptibility of {A}nopheles species, including several malaria vectors ({A}n. maculatus and {A}n. minimus), to various insecticides was investigated in ten provinces of {L}ao {PDR} through a north-south transect. {B}ioassays were performed on field caught female mosquitoes using the standard {WHO} susceptibility tests with {DDT} (4%), deltamethrin (0.05%) and permethrin (0.75%). {I}n addition, the {DIIS}6 region of the para-type sodium channel gene was amplified and sequenced to identify knockdown resistance mutations (kdr). {R}esistance to {DDT} and permethrin was detected in suspected malaria vectors, such as {A}n. nivipes and {A}n. philippinensis in {L}ao {PDR}. {R}esistance to the formerly used {DDT} was found in a population of {A}n. maculatus s.l. from {L}uang {P}rabang province. {N}o resistance to pyrethroids was found in primary vectors, indicating that these insecticides are still adequate for malaria vector control. {H}owever, high resistance levels to pyrethroids was found in-vector species and reduced susceptibility to permethrin in {A}n. minimus and {A}n. maculatus was reported in specific localities which raises concerns for pyrethroid-based control in the future. {N}o kdr mutation was found in any of the resistant populations tested hence suggesting a probable role detoxification enzymes in resistance. {T}his study highlights the necessity to continue the monitoring of insecticide susceptibility to early detect potential occurrence and/or migration of insecticide resistance in malaria vectors in {L}ao {PDR}.},
  keywords = {{LAOS}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {12},
  numero = {4},
  pages = {e0175984 [13 p.]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0175984},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069991},
}