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Marcombe S., Bobichon J., Somphong B., Phommavan N., Maithaviphet S., Nambanya S., Corbel Vincent, Brey P. T. (2017). Insecticide resistance status of malaria vectors in Lao PDR. Plos One, 12 (4), e0175984 [13 p.]. ISSN 1932-6203

Fichier PDF disponible http://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-05/010069991.pdf

Lien direct chez l'éditeur doi:10.1371/journal.pone.0175984

Insecticide resistance status of malaria vectors in Lao PDR
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000400287600026
AuteursMarcombe S., Bobichon J., Somphong B., Phommavan N., Maithaviphet S., Nambanya S., Corbel Vincent, Brey P. T.
SourcePlos One, 2017, 12 (4), p. e0175984 [13 p.]. p. e0175984 [13 p.] ISSN 1932-6203
RésuméKnowledge on insecticide resistance in Anopheles species is a basic requirement to guide malaria vector control programs. In Lao PDR, vector control relies on insecticide residual spraying (IRS) and impregnated bed-nets (ITNs) with the use of pyrethroids. Here, the susceptibility of Anopheles species, including several malaria vectors (An. maculatus and An. minimus), to various insecticides was investigated in ten provinces of Lao PDR through a north-south transect. Bioassays were performed on field caught female mosquitoes using the standard WHO susceptibility tests with DDT (4%), deltamethrin (0.05%) and permethrin (0.75%). In addition, the DIIS6 region of the para-type sodium channel gene was amplified and sequenced to identify knockdown resistance mutations (kdr). Resistance to DDT and permethrin was detected in suspected malaria vectors, such as An. nivipes and An. philippinensis in Lao PDR. Resistance to the formerly used DDT was found in a population of An. maculatus s.l. from Luang Prabang province. No resistance to pyrethroids was found in primary vectors, indicating that these insecticides are still adequate for malaria vector control. However, high resistance levels to pyrethroids was found in-vector species and reduced susceptibility to permethrin in An. minimus and An. maculatus was reported in specific localities which raises concerns for pyrethroid-based control in the future. No kdr mutation was found in any of the resistant populations tested hence suggesting a probable role detoxification enzymes in resistance. This study highlights the necessity to continue the monitoring of insecticide susceptibility to early detect potential occurrence and/or migration of insecticide resistance in malaria vectors in Lao PDR.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052]
Descr. géo.LAOS
LocalisationFonds IRD [F B010069991]
Identifiant IRDfdi:010069991
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010069991

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