@article{fdi:010069990,
  title = {{I}nfluence of host factors and parasite biomass on the severity of imported {P}lasmodium falciparum malaria},
  author = {{A}rgy, {N}. and {K}endjo, {E}. and {A}uge-{C}ourtoi, {C}. and {C}ojean, {S}. and {C}lain, {J}. and {H}ouze, {P}. and {T}hellier, {M}. and {H}ubert, {V}. and {D}eloron, {P}hilippe and {H}ouze, {S}. and {C}nrp {S}tudy {G}roup,},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives {I}mported malaria in {F}rance is characterized by various clinical manifestations observed in a heterogeneous population of patients such as travelers/expatriates and {A}frican migrants. {I}n this population, host factors and parasite biomass associated with severe imported malaria are poorly known. {M}ethods {F}rom data collected by the {C}entre {N}ational de {R}eference du {P}aludisme, we identified epidemiological, demographic and biological features including parasite biomass and anti-plasmodial antibody levels (negative, positive and strongly positive serology) associated with different disease severity groups (very severe, moderately severe, and uncomplicated malaria) in 3 epidemiological groups (travelers/expatriates, first-and second-generation migrants). {R}esults {A}ge, ethnicity, absence of prior infection with {P}. falciparum, antibody levels, plasma {P}f{HRP}2 levels, total and circulating parasite biomass were related to severe malaria onset. {S}equestered parasite biomass tended to be increased in very severe malaria, and was strongly correlated to the antibody level of the host. {C}onclusions {P}rior exposure to {P}. falciparum is associated with high anti-plasmodial antibody levels which influence clinical presentation of imported malaria and its correlated circulating and sequestered parasite burden.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {12},
  numero = {4},
  pages = {e0175328 [16 p.]},
  ISSN = {1932-6203},
  year = {2017},
  DOI = {10.1371/journal.pone.0175328},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069990},
}