@article{fdi:010069985,
  title = {{H}igh prevalence and diversity of hepatitis viruses in suspected cases of yellow fever in the {D}emocratic {R}epublic of {C}ongo},
  author = {{M}akiala-{M}andanda, {S}. and {L}e {G}al, {F}. and {N}gwaka-{M}atsung, {N}. and {A}huka-{M}undeke, {S}. and {O}nanga, {R}. and {B}ivigou-{M}boumba, {B}. and {P}ukuta-{S}imbu, {E}. and {G}erber, {A}. and {A}bbate, {J}. {L}. and {M}wamba, {D}. and {B}erthet, {N}. and {L}eroy, {E}ric and {M}uyembe-{T}amfum, {J}. {J}. and {B}ecquart, {P}ierre},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he majority of patients with acute febrile jaundice (>95%) identified through a yellow fever surveillance program in the {D}emocratic {R}epublic of {C}ongo ({DRC}) test negative for antibodies against yellow fever virus. {H}owever, no etiological investigation has ever been carried out on these patients. {H}ere, we tested for hepatitis {A} ({HAV}), hepatitis {B} ({HBV}), hepatitis {C} ({HCV}), hepatitis {D} ({HDV}), and hepatitis {E} ({HEV}) viruses, all of which can cause acute febrile jaundice, in patients included in the yellow fever surveillance program in the {DRC}. {O}n a total of 498 serum samples collected from suspected cases of yellow fever from {J}anuary 2003 to {J}anuary 2012, enzyme-linked immunosorbent assay ({ELISA}) techniques were used to screen for antibodies against {HAV} ({I}g{M}) and {HEV} ({I}g{M}) and for antigens and antibodies against {HBV} ({HB}s{A}g and anti-hepatitis {B} core protein [{HB}c] {I}g{M}, respectively), {HCV}, and {HDV}. {V}iral loads and genotypes were determined for {HBV} and {HVD}. {V}iral hepatitis serological markers were diagnosed in 218 (43.7%) patients. {T}he seroprevalences were 16.7% for {HAV}, 24.6% for {HBV}, 2.3% for {HCV}, and 10.4% for {HEV}, and 26.1% of {HBV}-positive patients were also infected with {HDV}. {M}edian viral loads were 4.19 x 10(5) {IU}/ml for {HBV} (range, 769 to 9.82 x 10(9) {IU}/ml) and 1.4 x 10(6) {IU}/ml for {HDV} (range, 3.1 x 10(2) to 2.9 x 10(8) {IU}/ml). {G}enotypes {A}, {E}, and {D} of {HBV} and genotype 1 of {HDV} were detected. {T}hese high hepatitis prevalence rates highlight the necessity to include screening for hepatitis viruses in the yellow fever surveillance program in the {DRC}.},
  keywords = {{DRC} ; hepatitis virus ; yellow fever surveillance ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{J}ournal of {C}linical {M}icrobiology},
  volume = {55},
  numero = {5},
  pages = {1299--1312},
  ISSN = {0095-1137},
  year = {2017},
  DOI = {10.1128/jcm.01847-16},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069985},
}